ANRS CO21 CODEX - Multicentric cohort of HIV patients with extreme progression profiles
Head :
Lambotte Olivier, U1184 Immunité Virale et auto-immunité
Last update : 08/08/2020 | Version : 2 | ID : 6744
| General | |
| Identification | |
| Detailed name | Multicentric cohort of HIV patients with extreme progression profiles |
| Sign or acronym | ANRS CO21 CODEX |
| CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation | CPP IdF VII le 25/7/2011 n° 11-033 ; autorisation AFSSAPS AEC/B110900-40 |
| General Aspects | |
| Medical area |
Hematology Immunology Infectious diseases |
| Health determinants |
Lifestyle and behavior Medicine |
| Keywords | Extreme progression, CD4+ lymphocytes, asymptomatic, antiretroviral treatment |
| Scientific investigator(s) (Contact) | |
| Name of the director | Lambotte |
| Surname | Olivier |
| Address | 63 rue Gabriel Péri 94276 Le Kremlin Bicêtre |
| Phone | 33 (0)1 49 59 67 54 |
| olivier.lambotte@bct.aphp.fr | |
| Unit | U1184 Immunité Virale et auto-immunité |
| Organization | Université Paris Sud, Institut National de la Santé et de la Recherche |
| Collaborations | |
| Participation in projects, networks and consortia |
Yes |
| Funding | |
| Funding status |
Public |
| Details | Agence Nationale de Recherche sur le Sida |
| Governance of the database | |
| Sponsor(s) or organisation(s) responsible | Agence Nationale de Recherche sur le Sida |
| Organisation status |
Public |
| Presence of scientific or steering committees |
Yes |
| Additional contact | |
| Main features | |
| Type of database | |
| Type of database |
Study databases |
| Study databases (details) |
Cohort study |
| Database recruitment is carried out by an intermediary |
A selection of health institutions and services |
| Database recruitment is carried out as part of an interventional study |
No |
| Additional information regarding sample selection. | Sample includes: - Long-term asymptomatic subjects with HIV-1 for at least 8 years with a CD4 count above 600/mm3, with a stable or increasing rate (positive or zero slope) during the last 5 years regardless of the viral load in the absence of antiretroviral treatment - Subjects who have been HIV-1 seropositive for at least five years (HIC group), asymptomatic, with the last 5 viral loads at 400 copies/mL regardless of CD4 lymphocyte count in the absence of antiretroviral treatment - subjects meeting the dual definition the ALT and HIC group |
| Database objective | |
| Main objective | To study the clinical and immunovirological progression of patients infected with HIV, and to determine the virus and host parameters associated with non-progression of infection. |
| Inclusion criteria | - Men or women - between 18 and 85 years old - covered by social security - subject infected with HIV-1 but not receiving antiretroviral treatment |
| Population type | |
| Age |
Adulthood (19 to 24 years) Adulthood (25 to 44 years) Adulthood (45 to 64 years) Elderly (65 to 79 years) Great age (80 years and more) |
| Population covered |
Sick population |
| Pathology | U60 - |
| Gender |
Male Woman |
| Geography area |
National |
| Detail of the geography area | France |
| Data collection | |
| Dates | |
| Date of first collection (YYYY or MM/YYYY) | 2009 |
| Size of the database | |
| Size of the database (number of individuals) |
< 500 individuals |
| Details of the number of individuals | 222 |
| Data | |
| Database activity |
Current data collection |
| Type of data collected |
Declarative data Biological data |
| Declarative data (detail) |
Paper self-questionnaire |
| Biological data (detail) | - serum - plasma - cells |
| Presence of a biobank |
Yes |
| Contents of biobank |
Serum Plasma Blood cells isolated |
| Details of biobank content | Cell bank retained by INSERM Unit U1012. Available for research projects subject to the opinion of the Scientific Council. |
| Health parameters studied |
Health event/morbidity Health event/mortality |
| Procedures | |
| Data collection method | Data on clinical events, virological, genetic and immunological parameters associated with non-progression. |
| Participant monitoring |
Yes |
| Monitoring procedures |
Monitoring by contact with the referring doctor |
| Details on monitoring of participants | Study duration of six years with a minimum of one annual visit. |
| Links to administrative sources |
No |
| Promotion and access | |
| Promotion | |
| Link to the document | http://clinicaltrials.gov/show/NCT01520844 |
| Link to the document | http://www.ncbi.nlm.nih.gov/pubmed/?term=ANRS+C021+OR+ANRS+CO21+OR+%28codex+AND+Anrs%29 |
| Description | List of publications in Pubmed |
| Access | |
| Dedicated website | https://cesp.inserm.fr |
| Terms of data access (charter for data provision, format of data, availability delay) | Data available for collaboration requests by research teams who wish to work with the cohort teams. |
| Access to aggregated data |
Access on specific project only |
| Access to individual data |
Access on specific project only |
