COLOMBES - Louis Mourier Cohort: Severe and Morbid Obesity: Assessment, Evaluation and Follow-Up
Head :
De Prost Dominique, AP-HP, LABORATOIRE D'HÉMATOLOGIE, HÔPITAL LOUIS MOURIER AP-HP
Msika Simon, SERVICE DE CHIRURGIE, HÔPITAL LOUIS MOURIER AP-HP
Msika Simon, SERVICE DE CHIRURGIE, HÔPITAL LOUIS MOURIER AP-HP
Last update : 07/01/2015 | Version : 2 | ID : 60013
| General | |
| Identification | |
| Detailed name | Louis Mourier Cohort: Severe and Morbid Obesity: Assessment, Evaluation and Follow-Up |
| Sign or acronym | COLOMBES |
| CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation | CNIL : 11/04/2006 |
| General Aspects | |
| Medical area |
Endocrinology and metabolism |
| Health determinants |
Nutrition |
| Scientific investigator(s) (Contact) | |
| Name of the director | De Prost |
| Surname | Dominique |
| Address | 92701 COLOMBES |
| Phone | +33 (0)1 47 60 61 13 |
| dominique.de-prost@lmr.aphp.fr | |
| Unit | AP-HP, LABORATOIRE D'HÉMATOLOGIE, HÔPITAL LOUIS MOURIER AP-HP |
| Organization | APHP |
| Name of the director | Msika |
| Surname | Simon |
| Address | 92701 COLOMBES |
| Phone | +33 (0)1 47 60 61 62 |
| simon.msika@lmr.aphp.fr | |
| Unit | SERVICE DE CHIRURGIE, HÔPITAL LOUIS MOURIER AP-HP |
| Organization | APHP |
| Collaborations | |
| Participation in projects, networks and consortia |
Yes |
| Funding | |
| Funding status |
Public |
| Details | AP-HP, direction de la recherche clinique - AP-HP, unité de recherche clinique Paris nord - AP-HP, hôpital Louis Mourier |
| Governance of the database | |
| Sponsor(s) or organisation(s) responsible | AP-HP |
| Organisation status |
Public |
| Additional contact | |
| Main features | |
| Type of database | |
| Type of database |
Study databases |
| Study databases (details) |
Longitudinal study (except cohorts) |
| Database recruitment is carried out by an intermediary |
A selection of health institutions and services |
| Database recruitment is carried out as part of an interventional study |
No |
| Additional information regarding sample selection. | Prospective Inclusion cut-off date: 01/06/2009 |
| Database objective | |
| Main objective | To provide a collection of clinical, prognostic, biological and histological data that is gathered from morbidly obese patients in standardised conditions and prospectively monitor subjects over a 10-year period. Secondary objective: To gather voluntary subjects to participate in other research projects regarding obesity (impact of bariatric surgery and prognostic factors of its success or failure; research into cardiovascular, metabolic, diagnostic and prognostic factors associated with obesity and its complications, ...) |
| Inclusion criteria | BMI >= 35 kg/m² Age: [18-60] years old |
| Population type | |
| Age |
Adulthood (19 to 24 years) Adulthood (25 to 44 years) Adulthood (45 to 64 years) |
| Population covered |
Sick population |
| Gender |
Male Woman |
| Geography area |
Regional |
| French regions covered by the database |
Île-de-France |
| Detail of the geography area | Ile de France |
| Data collection | |
| Dates | |
| Date of first collection (YYYY or MM/YYYY) | 03/2005 |
| Date of last collection (YYYY or MM/YYYY) | 06/2019 |
| Size of the database | |
| Size of the database (number of individuals) |
< 500 individuals |
| Details of the number of individuals | 288 |
| Data | |
| Database activity |
Current data collection |
| Type of data collected |
Clinical data Declarative data Paraclinical data Biological data |
| Clinical data (detail) |
Direct physical measures Medical registration |
| Declarative data (detail) |
Paper self-questionnaire Face to face interview |
| Paraclinical data (detail) | - Knee x-rays - Audio scan Patients who have undergone surgery (bariatric surgery): - OGD endoscopy transit, oesophageal manometry, 24-hour pH monitoring, glucose breath test, liver ultrasound - Ventilatory polygraphy |
| Biological data (detail) | Blood (systematic dosage): - FBC, haemostasis - Lipid profile - Liver function tests - Fibrinogen, US-CRP - Glucose and insulin level, Renal profile, TSH, DNA (buccal mucosa or blood) Tissue (fat, liver) |
| Presence of a biobank |
Yes |
| Contents of biobank |
Serum Plasma DNA Others |
| Details of biobank content | Serum bank, plasma bank, DNA bank, histology slides |
| Health parameters studied |
Health event/morbidity Health event/mortality Quality of life/health perception |
| Procedures | |
| Data collection method | - Self-administered questionnaire: manual input from a paper questionnaire with double data entry - Interview: manual input from a paper questionnaire with double data entry - Clinical Examinations: handwritten with double data entry - Biological analysis: handwritten with double data entry |
| Participant monitoring |
Yes |
| Details on monitoring of participants | Duration: 10 years |
| Links to administrative sources |
No |
| Promotion and access | |
| Promotion | |
| Link to the document | http://www.ncbi.nlm.nih.gov/pubmed/23512861 |
| Access | |
| Terms of data access (charter for data provision, format of data, availability delay) | Data may be used by academic teams or by industrial teams under contract outlining the temporary terms of data usage, according to the decision of the Scientific Committee and AP-HP Department of Clinical Research. |
| Access to aggregated data |
Access on specific project only |
| Access to individual data |
Access on specific project only |
