ISAAC - International Study of Asthma and Allergies in Childhood in France 
Head :
Annesi-Maesano Isabella, UMRS 707 : Épidémiologie, systèmes d'information, modélisationÉpidémiologie des maladies allergiques et respiratoires EPAR
Last update : 09/05/2017 | Version : 1 | ID : 8272
| General | |
| Identification | |
| Detailed name | International Study of Asthma and Allergies in Childhood in France |
| Sign or acronym | ISAAC |
| CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation | CNIL agreement |
| General Aspects | |
| Medical area |
Pediatrics Study of allergies |
| Health determinants |
Genetic Lifestyle and behavior Pollution Social and psychosocial factors |
| Keywords | skin test, air pollution, child, environment, allergy |
| Scientific investigator(s) (Contact) | |
| Name of the director | Annesi-Maesano |
| Surname | Isabella |
| Address | 27, rue de Chaligny 75012 Paris |
| Phone | +33 (0)1 44 73 84 49 |
| annesi@u707.jussieu.fr | |
| Unit | UMRS 707 : Épidémiologie, systèmes d'information, modélisationÉpidémiologie des maladies allergiques et respiratoires EPAR |
| Organization | Institut national de la santé et de la recherche médicale - |
| Collaborations | |
| Participation in projects, networks and consortia |
Yes |
| Details | During ECHRS paediatrics. The project involves six hospital departments (Clermont-Ferrand, Marseille, Bordeaux, Reims, Strasbourg, Paris) and three specialist teams: • epidemiology team: Dr I. Annesi-Maesano, G. Debotte, INSERM U 472), • paediatric team: Prof. P. Scheinman, Dr. C. Karila, Dr. E. Paty (Necker-Enfants Malades Hospital, Paris); • metrology team: M. Squinazi, Y. Le Moullec, M. Laurent (laboratoire d’hygiène de la ville de Paris [The City of Paris Hygiene Laboratory]). |
| Funding | |
| Funding status |
Public |
| Details | - National Institute for Healthcare and Medical Research - Ministry of Employment and Solidarity - Mutuelle Générale de l’Éducation Nationale - Agency for the Environment and Energy Management, ADEME/PRIMEQUAL 96 |
| Governance of the database | |
| Sponsor(s) or organisation(s) responsible | Institut national de la santé et de la recherche médicale - Inserm |
| Organisation status |
Public |
| Additional contact | |
| Main features | |
| Type of database | |
| Type of database |
Study databases |
| Study databases (details) |
Not-repeated cross-sectional studies (except case control studies) |
| Database recruitment is carried out by an intermediary |
A population file |
| Database recruitment is carried out as part of an interventional study |
No |
| Additional information regarding sample selection. | Sample of children with average age of 10.4 (plus or minus standard deviation), plus or minus 0.7 years, from 108 schools and 401 classes. |
| Database objective | |
| Main objective |
To establish a global map of the prevalence of childhood allergic diseases and to determine the risk factors for these diseases by comparing contrasting population groups based on a particularly strong or weak prevalence.
The ISAAC study consists of three phases: The objective of Phase I is to assess the prevalence of asthma, allergic rhinitis and eczema by using a simple questionnaire and possible video questionnaire (for asthma), in representative samples of children from two age groups: 13-14 years old (obligatory for all centres) and 6-7 years old (optional). Phase II aims to identify the risk factors and treatment procedures for allergic diseases through a more detailed study of selected population groups with relatively high or low prevalence rates suggested during Phase I. Phase III aims to assess the trends in allergy prevalence. As such, the Phase I protocol will be repeated in areas that participated in this phase. |
| Inclusion criteria |
- primary school children
- between 8 and 13 years old |
| Population type | |
| Age |
Childhood (6 to 13 years) |
| Population covered |
General population |
| Gender |
Male Woman |
| Geography area |
International |
| Detail of the geography area | One hundred and fifty-six centres in 56 countries: North America, Central America, South America, Western Europe, Central Europe (Albania, Germany, Estonia, Spain, France, Greece, Iceland, Italy, Norway, Netherlands , Portugal, U.K., Sweden), the Baltic States, Far East, Western Pacific, Anglophone Africa, Francophone Africa, Southeast Asia, East Mediterranean countries and Oceania. In France (primary schools in six French cities: Créteil, Clermont-Ferrand, Bordeaux, Marseille, Reims, Strasbourg). |
| Data collection | |
| Dates | |
| Date of first collection (YYYY or MM/YYYY) | 03/1999 |
| Date of last collection (YYYY or MM/YYYY) | 10/2000 |
| Size of the database | |
| Size of the database (number of individuals) |
[1000-10 000[ individuals |
| Details of the number of individuals | Monde/World: 721 601 France: 7 432 |
| Data | |
| Database activity |
Data collection completed |
| Type of data collected |
Clinical data Declarative data Paraclinical data Biological data |
| Clinical data (detail) |
Medical registration |
| Details of collected clinical data | Allergy assessment: skin prick tests, Williams standardised skin test (eczema), free running test, with peak respiratory flow (bronchial hyper-reactivity). |
| Declarative data (detail) |
Paper self-questionnaire |
| Details of collected declarative data | Parent questionnaire assessing the child's personal and family history, respiratory symptoms and domestic environment (allergen exposure, passive smoking, psychosocial factors) |
| Paraclinical data (detail) | Anthropometric measurements (height, weight, hip contour , head circumference) |
| Biological data (detail) | urine and hair cotinine research (nicotine metabolite), inflammation and lead markers |
| Presence of a biobank |
No |
| Health parameters studied |
Health event/morbidity |
| Procedures | |
| Data collection method | Pollutants measured in school yards and measurements collected by urban air quality monitoring networks: - SO2, FN, NOx, NO2, O3 and PM using collective measurements (city monitoring networks) (macroenvironment); - NOx, NO2, O3, VOC (formaldehyde) and PM using passive sensors within schools (microenvironment); - NO2, O3, COV. using individual badges as part of the panel (individual). Each centre can choose the protocol best suited to them. However, a minimum protocol was agreed at European level. |
| Participant monitoring |
No |
| Links to administrative sources |
No |
| Promotion and access | |
| Promotion | |
| Link to the document | http://erj.ersjournals.com/content/24/3/406.long |
| Link to the document | http://www.sciencedirect.com/science/article/pii/S0335745708001342 |
| Link to the document | http://www.annallergy.org/article/S1081-1206%2810%2960598-4/abstract |
| Link to the document | http://www.resmedjournal.com/article/S0954-6111%2807%2900099-6/abstract |
| Link to the document | http://www.resmedjournal.com/article/S0954-6111%2806%2900221-6/abstract |
| Link to the document | http://www.sciencedirect.com/science/article/pii/S1352231005010575 |
| Link to the document | http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2222.2005.02336.x/abstract;jsessionid |
| Link to the document | http://onlinelibrary.wiley.com/doi/10.1111/j.1398-9995.2005.00860.x/abstract |
| Link to the document | http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2222.2004.02002.x/abstract |
| Access | |
| Terms of data access (charter for data provision, format of data, availability delay) | Contact the scientist in charge |
| Access to aggregated data |
Access on specific project only |
| Access to individual data |
Access on specific project only |
