MESONAT - French registry of pleural mesothelioma cases
Head :
Galateau-Salle Françoise, Groupe Mésopath. Laboratoire d'ANATOMIE PATHOLOGIQUE, CHU CAEN 14033 Caen CedexERI 3 Inserm ‘’Cancers et Populations’’
Last update : 02/05/2016 | Version : 2 | ID : 227
| General | |
| Identification | |
| Detailed name | French registry of pleural mesothelioma cases |
| Sign or acronym | MESONAT |
| CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation | CNIL 998100 |
| General Aspects | |
| Medical area |
Cancer research Rare diseases |
| Health determinants |
Iatrogenic Occupation |
| Keywords | asbestos, other fibers, genetics., environment, irradiation |
| Scientific investigator(s) (Contact) | |
| Name of the director | Galateau-Salle |
| Surname | Françoise |
| Address | Registre MESONAT- Groupe Mésopath ERI 3 Inserm ‘’Cancers et Populations’’ CHU Caen - BP 95182, 14033 Caen Cedex |
| Phone | + 33 (0)2 31 06 44 07 |
| galateausalle-f@chu-caen.fr | |
| Unit | Groupe Mésopath. Laboratoire d'ANATOMIE PATHOLOGIQUE, CHU CAEN 14033 Caen CedexERI 3 Inserm ‘’Cancers et Populations’’ |
| Organization | CHU |
| Collaborations | |
| Funding | |
| Funding status |
Public |
| Details | Institut de veille sanitaire - InVS |
| Governance of the database | |
| Sponsor(s) or organisation(s) responsible | CHU Caen |
| Organisation status |
Public |
| Additional contact | |
| Main features | |
| Type of database | |
| Type of database |
Morbidity registers |
| Additional information regarding sample selection. |
Selection of subjects having the required inclusion criteria.
The sources called on for collecting cases can vary from département to département, but they systematically rely on public and private anatomopathology laboratories, public and private hospital departments of pneumology, thoracic surgery, internal medicine and oncology, occupational disease appointments (when these exist), the medical department of the Primary Health Insurance Funds (CPAMs) and other social security schemes (chronic disease applications) as well as medical information departments (DIMs). |
| Database objective | |
| Main objective |
The registry is the kingpin of the PNSM (National Program for Mesothelioma Surveillance) and forms the basic tool of the national system for epidemiological mesothelioma surveillance for the purposes of public health. This surveillance includes in particular:
- Estimation of national incidence: an incidence/mortality ratio is established on the basis of data from the départements covered by the registry and applied to national mortality data by age range, whole of France, with men and women considered separately. - Improvement in the anatomopathological diagnosis of mesothelioma - Description of the activity sectors and at-risk professions for mesothelioma in men: the economic activity sectors and professions are grouped according to the degree of pleural mesothelioma risk. - Establishment of attributable fractions: the risk fraction attributable to occupational asbestos exposure in men has been put overall at 83.2% (CI 95%: 76.8-89.6); more in-depth analyses are in the pipeline. - Evaluation of mesothelioma treatment as an occupational disease; this is another branch of systematic analysis because the level of recognition is insufficient overall. |
| Inclusion criteria | The cases recorded are of patients living in the départements described below who presented the first signs of pleural mesothelioma from 1998 to the current year. |
| Population type | |
| Age |
Adolescence (13 to 18 years) Adulthood (19 to 24 years) Adulthood (25 to 44 years) Adulthood (45 to 64 years) Elderly (65 to 79 years) Great age (80 years and more) |
| Population covered |
Sick population |
| Gender |
Male Woman |
| Geography area |
National |
| Detail of the geography area | 22 departments in 2008 : Calvados (14), Dordogne (24), Doubs (25), Gironde (33), Isère (38), Landes (40), Loire-Atlantique (44), Lot-et-Garonne (47), Manche (50), Orne (61), Pyrénées-Atlantiques (64), Bas-Rhin (67), Haut-Rhin (68), Somme (80), Bouches-du-Rhône (13), Var (83) et Seine-Saint-Denis (93), Val-de-Marne (94), Alpes-Maritimes (06), Haute-Corse (2B), Corse-du-Sud (2A) et Seine-Maritime (76) |
| Data collection | |
| Dates | |
| Date of first collection (YYYY or MM/YYYY) | 1998 |
| Size of the database | |
| Size of the database (number of individuals) |
< 500 individuals |
| Details of the number of individuals | 1998-2006 : 1900 (238/an/year) |
| Data | |
| Database activity |
Current data collection |
| Type of data collected |
Clinical data Paraclinical data Biological data Administrative data |
| Clinical data (detail) |
Direct physical measures |
| Details of collected clinical data | > Cancer antecedents > Tumor: location, date of initial diagnosis, date of first sample, sample recording date, diagnostic method (clinic & biologic, paraclinic, cytology/histology), tumor morphology, WHO grade, tumor size, tumor stage, metastasis > Treatments: date of first treatment, surgery, chemotherapy, radiotherapy, palliative |
| Paraclinical data (detail) | anatomopathological lesion |
| Biological data (detail) | markers |
| Administrative data (detail) | > Demographic: date of birth, gender, place of birth, current residence, name and address of their physician(s), health insurance regimen |
| Presence of a biobank |
Yes |
| Contents of biobank |
Tissues DNA DNAc/RNAm |
| Details of biobank content | cryopreserved tissuetissues included in paraffinDNADNAc/RNAm |
| Health parameters studied |
Health event/morbidity Health event/mortality |
| Procedures | |
| Data collection method | letters, emails, visits, phone calls and passive collection. |
| Classifications used | CIM0/CIM10/ADICAP |
| Participant monitoring |
Yes |
| Details on monitoring of participants | - sample-based for specific studies- vital status (in some départements and for specific studies) once a year |
| Links to administrative sources |
Yes |
| Linked administrative sources (detail) | PMSI |
| Promotion and access | |
| Promotion | |
| Link to the document | Mesobank.pdf |
| Access | |
| Terms of data access (charter for data provision, format of data, availability delay) | Biannual bulletin to the InVS (French Institute for Public Health Surveillance), by request and upon publication. |
| Access to aggregated data |
Access on specific project only |
| Access to individual data |
Access on specific project only |
