BACAP - Anatomical-Clinical Pancreatic Adenocarcinoma Database
Head :
Bournet Barbara, Gastro-entérologie et nutrition
Canivet Cindy
Canivet Cindy
Last update : 11/09/2018 | Version : 1 | ID : 38993
| General | |
| Identification | |
| Detailed name | Anatomical-Clinical Pancreatic Adenocarcinoma Database |
| Sign or acronym | BACAP |
| CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation | CNIL: 913462; Collection declaration No.: DC-2013-1974 |
| General Aspects | |
| Medical area |
Cancer research Gastroenterology et hepatology |
| Pathology (details) | Adenocarcinoma of pancreas |
| Health determinants |
Genetic Lifestyle and behavior Medicine Nutrition Occupation |
| Keywords | Clinical data, biological specimens, pancreatic carcinogenesis, therapeutic target, cachexia, biomarker, proteomics signature, genomic DNA, microparticles, diagnosis, screening, microRNA |
| Scientific investigator(s) (Contact) | |
| Name of the director | Bournet |
| Surname | Barbara |
| Address |
Gastroenterology and Nutrition Department Hôpital Rangueil 1 avenue Jean Poulhes 31059 Toulouse cedex 9 |
| Phone | (+33) 5 61 32 27 61 |
| bournet.b@chu-toulouse.fr | |
| Unit | Gastro-entérologie et nutrition |
| Organization | CHU Toulouse |
| Name of the director | Canivet |
| Surname | Cindy |
| Phone | +33 (0)5 61 32 20 48 |
| canivet.c@chu-toulouse.fr | |
| Organization | CHU Toulouse |
| Collaborations | |
| Participation in projects, networks and consortia |
Yes |
| Details | BACAP consists of a network of clinicians (physicians and surgeons), anatomical pathologists, epidemiologists, and researchers |
| Funding | |
| Funding status |
Public |
| Details | French National Cancer Institute (INCa) |
| Governance of the database | |
| Sponsor(s) or organisation(s) responsible | CHU Toulouse |
| Organisation status |
Public |
| Presence of scientific or steering committees |
Yes |
| Additional contact | |
| Main features | |
| Type of database | |
| Type of database |
Study databases |
| Study databases (details) |
Longitudinal study (except cohorts) |
| Database recruitment is carried out by an intermediary |
A selection of health institutions and services |
| Database recruitment is carried out as part of an interventional study |
No |
| Additional information regarding sample selection. | During diagnosis of the disease |
| Database objective | |
| Main objective |
The purpose of this project is to compile clinical data and data on biological specimens from patients with a pancreatic adenocarcinoma in order to make it available to the scientific community.
The purpose of BACAP is to support the following research projects: - understanding the development of pancreatic carcinogenesis, - the early diagnosis and screening of pancreatic cancer by identifying biomarkers of precancerous lesions (proteomics signature, microRNA, genomic dNA, microparticles) and associated thrombosis risk, - the development of new in vitro tools for diagnosing pancreatic cancer, - the clinical and biological evaluation of the development of cachexia in patients with pancreatic cancer, - the determination of factors responsible for spreading cancerous cells, especially inflammation markers, - the identification of biomarkers that indicate sensitivity or resistance to chemotherapy in pancreatic cancer, - the development of new therapeutic targets |
| Inclusion criteria | Patients with cytologically and/or histologically proven pancreatic adenocarcinoma |
| Population type | |
| Age |
Adulthood (19 to 24 years) Adulthood (25 to 44 years) Adulthood (45 to 64 years) Elderly (65 to 79 years) Great age (80 years and more) |
| Population covered |
Sick population |
| Pathology | C00-C75 - Malignant neoplasms, stated or presumed to be primary, of specified sites, except of lymphoid, haematopoietic and related tissue |
| Gender |
Male Woman |
| Geography area |
National |
| Detail of the geography area | 15 centres : Toulouse (CHU de Toulouse), Montpellier (Institut régional du Cancer de Montpellier et CHU de Montpellier), Marseille (Assistance Publique des Hôpitaux de Marseille - hôpital Nord et hopital La Timone), Nice (CHU de Nice - hôpital l’Archet), Lyon (hôpital privé Jean Mermoz et Centre Léon Bérard), Villejuif (Institut Gustave Roussy), Paris (Assistance Publique des Hôpitaux de Paris - hôpital Saint-Louis), Paris (Clinique du Trocadero), Lille (CHRU de Lille), Bordeaux (CHU de Bordeaux), Pau (CH de Pau) |
| Data collection | |
| Dates | |
| Date of first collection (YYYY or MM/YYYY) | 2014 |
| Date of last collection (YYYY or MM/YYYY) | undetermined |
| Size of the database | |
| Size of the database (number of individuals) |
[1000-10 000[ individuals |
| Details of the number of individuals | 1250 |
| Data | |
| Database activity |
Current data collection |
| Type of data collected |
Clinical data Declarative data Paraclinical data Biological data |
| Clinical data (detail) |
Direct physical measures |
| Details of collected clinical data | Imaging, biological assessment, clinical examination, treatments and side effects, weight progression, height, WHO performance index, medical comorbidities, history of other cancers, the date of first symptoms/description, diagnosis, tumour |
| Details of collected declarative data | Age, sex, level of education, employment, alcohol + tobacco consumption, risks of venous thromboembolism, cancer in the family |
| Paraclinical data (detail) | Biopsy, Endoscopic ultrasound, Tomodensitometry |
| Biological data (detail) | CBC, liver panel, glycaemia, tumoural markers |
| Presence of a biobank |
Yes |
| Contents of biobank |
Whole blood Serum Plasma Fluids (saliva, urine, amniotic fluid, …) Tissues DNA DNAc/RNAm |
| Details of biobank content | blood, serum, plasma, saliva, DNA-RNA of tumoural cells |
| Health parameters studied |
Health event/mortality |
| Procedures | |
| Data collection method | During patient visits to the corresponding hospital. Collection by clinicians (gastroenterologists, oncologists, surgeons) |
| Quality procedure(s) used | Clinsight software, the database is managed by the ICM data handling centre |
| Participant monitoring |
Yes |
| Monitoring procedures |
Monitoring by contact with the referring doctor |
| Details on monitoring of participants | at each clinical check-up and instance of patient imaging |
| Links to administrative sources |
No |
| Promotion and access | |
| Promotion | |
| Link to the document | Papier BACAP.pdf |
| Description | BACAP presentation publication |
| Access | |
| Presence of document that lists variables and coding procedures |
Yes |
| Terms of data access (charter for data provision, format of data, availability delay) | The data and the biological specimens are accessible upon request. The request form is accessible on the database website. Each request will be examined by the database's scientific committee. |
| Access to aggregated data |
Access on specific project only |
| Access to individual data |
Access on specific project only |
