KARU-PROSTATE - Case-Control Study on the Impact of Chlordecone Exposure and Risk of Prostate Cancer in the West Indies 
Head :
Multigner Luc , U1085 Research Institute of Health, Environment and Work
Last update : 09/05/2017 | Version : 1 | ID : 6732
| General | |
| Identification | |
| Detailed name | Case-Control Study on the Impact of Chlordecone Exposure and Risk of Prostate Cancer in the West Indies |
| Sign or acronym | KARU-PROSTATE |
| CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation | CNIL |
| General Aspects | |
| Medical area |
Cancer research Urology, andrology and nephrology |
| Pathology (details) | Prostate cancer |
| Health determinants |
Climate Geography Intoxication Nutrition |
| Keywords | chlordecone, West Indies, exposure, contamination, prostate |
| Scientific investigator(s) (Contact) | |
| Name of the director | Multigner |
| Surname | Luc |
| Address | 263 Avenue du Général Leclerc - Campus de Beaulieu - BAT 13 - 35042 RENNES |
| Phone | +33 (0)2 23 23 69 11 |
| luc.multigner@inserm.fr | |
| Unit | U1085 Research Institute of Health, Environment and Work |
| Organization | National Institute of Health and Medical Research |
| Collaborations | |
| Funding | |
| Funding status |
Public |
| Details | National Institute of Health and Medical Research — Rennes 1 University — Ministry of Health (Clinical Research Hospital Programme) — Ministry of Research (University of Guiana and West Indies Multi-Training Programme) — Health, Environment and Occupational Research Programme from the French Agency for Environmental and Occupational Health and Safety — Ministry for Overseas Departments — Directorate-General for Health — Health and Social Development Department of Guadeloupe — Cancer Research Association and The Guadeloupe Cancer League Committee |
| Governance of the database | |
| Sponsor(s) or organisation(s) responsible | Inserm - Institut national de la santé et de la recherche médicale |
| Organisation status |
Public |
| Additional contact | |
| Main features | |
| Type of database | |
| Type of database |
Study databases |
| Study databases (details) |
Case control study |
| Database recruitment is carried out by an intermediary |
A selection of health institutions and services |
| Database recruitment is carried out as part of an interventional study |
No |
| Additional information regarding sample selection. | Subjects recruited by urologists and controls at Health Examination Centres among men residing in the area. |
| Database objective | |
| Main objective | To identify the environmental and genetic risk factors of prostate cancer and to assess the impact of chlordecone exposure in the onset of the disease. |
| Inclusion criteria |
– Male
– Adult – Caribbean native (Guadeloupe, Martinique, Haiti, Dominica) |
| Population type | |
| Age |
Adulthood (19 to 24 years) Adulthood (25 to 44 years) Adulthood (45 to 64 years) |
| Population covered |
General population |
| Gender |
Male |
| Geography area |
National |
| Detail of the geography area | Guadeloupe, Martinique, Haiti, Dominica. |
| Data collection | |
| Dates | |
| Date of first collection (YYYY or MM/YYYY) | 2004 |
| Date of last collection (YYYY or MM/YYYY) | 2007 |
| Size of the database | |
| Size of the database (number of individuals) |
[1000-10 000[ individuals |
| Details of the number of individuals | 1294 – 623 cases – 671 controls |
| Data | |
| Database activity |
Data collection completed |
| Type of data collected |
Clinical data Declarative data Biological data |
| Clinical data (detail) |
Medical registration |
| Declarative data (detail) |
Paper self-questionnaire |
| Details of collected declarative data | Demographic and anthropomorphic characteristics; duration and places of residence since birth; lifestyle; professional data; family history of prostate cancer; medical history; drug use and prostate cancer screening history. Weight; height; waist and hip circumference. |
| Biological data (detail) | Blood sample |
| Presence of a biobank |
Yes |
| Contents of biobank |
Plasma DNA |
| Health parameters studied |
Health event/morbidity Others |
| Other (detail) | Exposure to chlordecone |
| Procedures | |
| Participant monitoring |
No |
| Links to administrative sources |
No |
| Promotion and access | |
| Promotion | |
| Link to the document | http://jco.ascopubs.org/content/28/21/3457.long#ack-1 |
| Access | |
| Terms of data access (charter for data provision, format of data, availability delay) | Contact the scientist in charge. |
| Access to aggregated data |
Access on specific project only |
| Access to individual data |
Access on specific project only |
