- Case-Control Study of Children with Hypospadias
Head :
Kalfa Nicolas
Last update : 08/17/2016 | Version : 1 | ID : 73141
| General | |
| Identification | |
| Detailed name | Case-Control Study of Children with Hypospadias |
| CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation | Mediterranean South Personal Protection Centre 4 (Centre de Protection des Personnes Sud Méditerranée), CPPSMIV, ID RCB 2008-A00781-54 |
| General Aspects | |
| Medical area |
Anatomy - Cytology Disability/handicap Rare diseases |
| Pathology (details) | Hypospadias |
| Health determinants |
Genetic Pollution |
| Keywords | sexual determination disorder, endocrine disrupting chemicals, birth defect, environment, profession, pesticides, hypospadias |
| Scientific investigator(s) (Contact) | |
| Name of the director | Kalfa |
| Surname | Nicolas |
| Phone | +33 (0)4 67 33 87 84 |
| nicolaskalfa@gmail.com | |
| Organization | Montpellier University Hospital |
| Collaborations | |
| Funding | |
| Funding status |
Public |
| Details | Montpellier University Hospital |
| Governance of the database | |
| Sponsor(s) or organisation(s) responsible | Montpellier University Hospital |
| Organisation status |
Public |
| Additional contact | |
| Main features | |
| Type of database | |
| Type of database |
Study databases |
| Study databases (details) |
Case control study |
| Database recruitment is carried out by an intermediary |
A selection of health institutions and services |
| Database recruitment is is made on the basis of: |
Another treatment or procedure |
| Database recruitment is carried out as part of an interventional study |
No |
| Database objective | |
| Main objective | The objective of the study is to identify the impact of occupational and environmental exposure to endocrine-disrupting chemicals on non-genetic, isolated hypospadias. |
| Inclusion criteria |
Children with hypospadias (from birth to 12 years old);
Controls: Normal children (no congenital, urological, genital or renal malformation; no inguinal hernia or endocrine diseases). Reasons for hospital admission were mainly acute appendicitis, idiopathic intestinal invagination, minor abdominal trauma and pyloric stenosis. |
| Population type | |
| Age |
Newborns (birth to 28 days) Infant (28 days to 2 years) Early childhood (2 to 5 years) Childhood (6 to 13 years) |
| Population covered |
Sick population |
| Gender |
Male |
| Geography area |
Local |
| French regions covered by the database |
Languedoc-Roussillon Midi-Pyrénées |
| Detail of the geography area | Montpellier |
| Data collection | |
| Dates | |
| Date of first collection (YYYY or MM/YYYY) | 2009 |
| Date of last collection (YYYY or MM/YYYY) | 2014 |
| Size of the database | |
| Size of the database (number of individuals) |
[500-1000[ individuals |
| Details of the number of individuals | 710 |
| Data | |
| Database activity |
Data collection completed |
| Type of data collected |
Declarative data |
| Declarative data (detail) |
Face to face interview |
| Details of collected declarative data | Parental occupational exposure to endocrine disruptors was assessed by the QLK4-1999-01422 questionnaire and a validated job-exposure matrix for endocrine-disrupting chemicals. Environmental exposure was assessed by postcode, type of environmental hazard and distance. |
| Presence of a biobank |
No |
| Health parameters studied |
Health event/morbidity |
| Procedures | |
| Data collection method | Questionnaire issued by the surgeon or endocrinologist. |
| Participant monitoring |
No |
| Links to administrative sources |
No |
| Promotion and access | |
| Promotion | |
| Link to the document | http://www.sciencedirect.com.gate2.inist.fr/science/article/pii/S0302283815004091 |
| Access | |
| Terms of data access (charter for data provision, format of data, availability delay) | Contact the scientist in charge. |
| Access to aggregated data |
Access on specific project only |
| Access to individual data |
Access on specific project only |
