E3N Study - The French E3N Prospective Cohort Study

Head :
Severi Gianluca, Inserm - Centre de Recherche en Epidémiologie et Santé des Populations (CESP) - Team Exposome and Heredity
Boutron-Ruault Marie-Christine, Inserm - Centre de Recherche en Epidémiologie et Santé des Populations (CESP) - Team Exposome and Heredity

Last update : 12/17/2020 | Version : 8 | ID : 3162

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Métadonnées
Identification
General Aspects
Scientific investigator(s) (Contact)
Collaborations
Funding
Governance of the database
Additional contact
Type of database
Database objective
Population type
Dates
Size of the database
Data
Procedures
Promotion
Access
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General
Identification
Detailed name The French E3N Prospective Cohort Study
Sign or acronym E3N Study
CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation CNIL n°327346 V 13, CPP (03/12/2008)
General Aspects
Medical area Biology
Cancer research
Cardiology
Dermatology, venereology
Disability/handicap
Endocrinology and metabolism
Gastroenterology et hepatology
Geriatrics
Gynecology/ obstetrics
Hematology
Infectious diseases
Neurology
Pneumology
Psychology and psychiatry
Radiology and medical imaging
Rheumatology
Study of allergies
Traumatology
Study in connection with Covid-19 Yes
Health determinants Genetic
Geography
Lifestyle and behavior
Medicine
Nutrition
Occupation
Pollution
Social and psychosocial factors
Scientific investigator(s) (Contact)
Name of the director Severi
Surname Gianluca
Address Gustave Roussy Institute,
Espace Maurice Tubiana,
114 rue Edouard Vaillant,
94805 Villejuif
Phone +33 (0)1 42 11 41 48
Email gianluca.severi@inserm.fr
Unit Inserm - Centre de Recherche en Epidémiologie et Santé des Populations (CESP) - Team Exposome and Heredity
Organization Inserm, Université Paris-Saclay, Institut Gustave Roussy
Name of the director Boutron-Ruault
Surname Marie-Christine
Address Gustave Roussy Institute,
Espace Maurice Tubiana,
114 rue Edouard Vaillant,
94805 Villejuif
Phone +33 (0)1 42 11 64 66
Unit Inserm - Centre de Recherche en Epidémiologie et Santé des Populations (CESP) - Team Exposome and Heredity
Organization Inserm, Université Paris-Saclay, Institut Gustave Roussy
Collaborations
Participation in projects, networks and consortia Yes
Details European EPIC study (European Prospective Investigation into Cancer and Nutrition)
Funding
Funding status Mixed
Details Ligue nationale contre le Cancer, Inserm, Gustave Roussy, MGEN, European Union (for the EPIC study) - Additional funding through call for projects
Governance of the database
Sponsor(s) or organisation(s) responsible Institut National de la Santé et de la Recherche Médicale - Inserm
Organisation status Public
Sponsor(s) or organisation(s) responsible Université Paris-Saclay
Organisation status Public
Sponsor(s) or organisation(s) responsible Institut Gustave Roussy
Organisation status Both
Organisation status
Presence of scientific or steering committees Yes
Additional contact
Main features
Type of database
Type of database Study databases
Study databases (details) Cohort study
Database recruitment is carried out by an intermediary A population file
Database recruitment is carried out as part of an interventional study No
Additional information regarding sample selection. In 1990, recruiting via an informative MGEN-INSERM letter sent along with an inclusion questionnaire to all women who are members of the MGEN and born between 1925 and 1950..
Database objective
Main objective Detecting risk factors of cancer and chronic pathologies in women
Inclusion criteria Women born between 1925 and 1950 and affiliated with MGEN (Mutuelle Générale de l'Education nationale)
Population type
Age Adulthood (45 to 64 years)
Elderly (65 to 79 years)
Great age (80 years and more)
Population covered General population
Pathology
Gender Woman
Geography area National
Detail of the geography area France
Data collection
Dates
Date of first collection (YYYY or MM/YYYY) 1990
Date of last collection (YYYY or MM/YYYY) 2020
Size of the database
Size of the database (number of individuals) Greater than 20 000 individuals
Details of the number of individuals 98 995
Data
Database activity Current data collection
Type of data collected Clinical data
Declarative data
Paraclinical data
Biological data
Administrative data
Clinical data (detail) Direct physical measures
Details of collected clinical data Anatomopathological report and / or hospital records to confirm and clarify the reported diseases
Declarative data (detail) Paper self-questionnaire
Internet self-questionnaire
Phone interview
Details of collected declarative data Lifestyle and health information
Paraclinical data (detail) imaging (mammographies....)
Biological data (detail) within the framework of case/controls studies: hormone levels, vitamin status, biomarkers
Administrative data (detail) identifying data
Presence of a biobank Yes
Contents of biobank Whole blood
Serum
Plasma
Fluids (saliva, urine, amniotic fluid, …)
Tissues
DNA
Details of biobank content Blood from a sample of 25,000 women taken between 1994 and 1998: erythrocytes, buffy coat (lymphocytes), serum, plasma. Saliva from a sample of 47,000 other women collected between 2009 and 2011. Tumor Bank : breast cancers' tumoral tissues
Health parameters studied Health event/morbidity
Health event/mortality
Health care consumption and services
Quality of life/health perception
Care consumption (detail) Hospitalization
Medical/paramedical consultation
Medicines consumption
Procedures
Data collection method Self-questionnaire at inclusion and then every three years during follow-up: Collection of data on the state of health, lifestyle, plus specific questionnaires under the responsibility of a researcher or for another project (on sub-samples).- Clinical examination at inclusion for a sub-sample of 25,000 women in the cohort: pulse, blood pressure, weight, height. Data collected between 1994 and 1998 when blood samples were taken.- Questionnaire with the general practitioners in the case of a pathology declared by the woman: confirmation and anatomopathological report for more than 80 % of cancers.
Classifications used ICD 9 and ICD 10
Participant monitoring Yes
Monitoring procedures Monitoring by contact with the participant (mail, e-mail, telephone etc.)
Monitoring by contact with the referring doctor
Monitoring by crossing with a medical-administrative database
Monitoring by crossing with a morbidity register
Details on monitoring of participants The duration of follow-up for the women participating in the study is undetermined, as the objective is to follow them as long as possible, until death.
Followed pathology C00-C97 - Malignant neoplasms
E10-E14 - Diabetes mellitus
G20 - Parkinson disease
N80 - Endometriosis
J45 - Asthma
I10-I15 - Hypertensive diseases
K50 - Crohn disease [regional enteritis]
K58 - Irritable bowel syndrome
F32 - Depressive episode
Links to administrative sources Yes
Linked administrative sources (detail) CépiDC, health insurance care reimbursement data (SNIIR-AM), MGEN
Promotion and access
Promotion
Link to the document http://www.hal.inserm.fr/E3N
Description List of publications in HAL
Link to the document http://www.ncbi.nlm.nih.gov/pubmed/?term=E3N-EPIC+OR+%28E3N+AND+%28cohort+OR+escape%29%29+NOT+23110838[uid]
Description List of publications in Pubmed
Link to the document http://epic.iarc.fr/
Link to the document https://www.e3n.fr/les-articles-scientifiques
Description List of the principal publications of the team
Access
Dedicated website https://www.e3n.fr
Presence of document that lists variables and coding procedures Yes
Terms of data access (charter for data provision, format of data, availability delay) Data access methods for outside teams: authorization request to the scientific committee of the E3N study
Access to aggregated data Access on specific project only
Access to individual data Access on specific project only

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