DéPasS - DEPRESSION – ANXIETY AND DISABIILTY IN A COHORT OF PATIENTS IN GENERAL MEDICINE PRACTICE 
Head :
Crochard Anne
Last update : 01/01/2020 | Version : 2 | ID : 178
| General | |
| Identification | |
| Detailed name | DEPRESSION – ANXIETY AND DISABIILTY IN A COHORT OF PATIENTS IN GENERAL MEDICINE PRACTICE |
| Sign or acronym | DéPasS |
| CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation | CNIL n° 909006 |
| General Aspects | |
| Medical area |
General practice Psychology and psychiatry |
| Keywords | depression, anxiety, functional disability, Sheehan, general practice, antidepressant |
| Scientific investigator(s) (Contact) | |
| Name of the director | Crochard |
| Surname | Anne |
| Address | 37-45 Quai du Président Roosevelt 92445 Issy-Les-Moulineaux |
| Phone | +33 (0)1 79 41 28 51 |
| acro@lundbeck.com | |
| Organization | Lundbeck |
| Collaborations | |
| Funding | |
| Funding status |
Private |
| Details | Lundbeck SAS Laboratory |
| Governance of the database | |
| Sponsor(s) or organisation(s) responsible | Lundbeck SAS |
| Organisation status |
Private |
| Additional contact | |
| Main features | |
| Type of database | |
| Type of database |
Study databases |
| Study databases (details) |
Longitudinal study (except cohorts) |
| Database recruitment is carried out by an intermediary |
A selection of health care professionals |
| Database recruitment is is made on the basis of: |
Medication(s) taken |
| Database recruitment is carried out as part of an interventional study |
No |
| Additional information regarding sample selection. | Selection of general practitioners: Study investigators were randomly selected from a list of 30 000 general practitioners, which in turn was derived from an exhaustive list of all general practitioners licensed by the national medical association in France and in active practice (CEGEDIM registry). All physicians were contacted by mail and invited to participate in the study. Selection of patients: each participating GP included around four eligible patients who spontaneously consulted for an anxiety or mood disorder during the three months following receipt of the study materials. |
| Database objective | |
| Main objective | To evaluate the change in self-reported personal, professional and social disability in patients with anxious or mood disorders three months after initiating antidepressant treatment. |
| Inclusion criteria |
Patient of at least 18 years of age
Patient having at least one of the 5 following diagnoses: major depressive episode (i.e. characterized) Generalized anxiety disorder Social anxiety disorder Panic disorder with or without agoraphobia Obsessive compulsive disorders Patient initiating a new treatment with an antidepressant Patient being able to communicate and to evaluate his quality of life Patient having received written information on the use of the medical data concerning himself within the framework of the study. |
| Population type | |
| Age |
Adulthood (19 to 24 years) Adulthood (25 to 44 years) Adulthood (45 to 64 years) Elderly (65 to 79 years) Great age (80 years and more) |
| Population covered |
Sick population |
| Gender |
Male Woman |
| Geography area |
National |
| Detail of the geography area | Metropolitan France |
| Data collection | |
| Dates | |
| Date of first collection (YYYY or MM/YYYY) | 2009 |
| Date of last collection (YYYY or MM/YYYY) | 2010 |
| Size of the database | |
| Size of the database (number of individuals) |
[1000-10 000[ individuals |
| Details of the number of individuals | 8 029 |
| Data | |
| Database activity |
Data collection completed |
| Type of data collected |
Clinical data Declarative data |
| Clinical data (detail) |
Direct physical measures |
| Declarative data (detail) |
Paper self-questionnaire |
| Presence of a biobank |
No |
| Health parameters studied |
Health event/morbidity Quality of life/health perception |
| Procedures | |
| Data collection method | Data collection was carried out at each visit on a voluntary and anonymous basis.Data were collected at the index consultation (inclusion visit) and at two follow-up consultations about 6 and 12 weeks after the index consultation. A window of ±2 weeks was considered acceptable for the 6-week visit and a window of ±3 weeks for the 12-week visit. These visits were programmed as part of the routine follow-up of the patients, and no additional protocol-specified study visit was imposed. Patients' disbility was evaluated with the Sheehan Disability Scale (SDS) at baseline and after six and twelve weeks.The patient's symptomatology was also filled in by the patient himself using the HAD self-questionnaire at each of three collection times scheduled in the protocol.Other data were collected by the physician himself. |
| Participant monitoring |
Yes |
| Details on monitoring of participants | 3 months |
| Links to administrative sources |
No |
| Promotion and access | |
| Promotion | |
| Link to the document | http://tinyurl.com/Hal-DEPASS |
| Description | List of publications in HAL |
| Link to the document | http://tinyurl.com/Pubmed-DEPASS |
| Description | List of publications in Pubmed |
| Access | |
| Terms of data access (charter for data provision, format of data, availability delay) | Publication in progress |
| Access to aggregated data |
Access on specific project only |
| Access to individual data |
Access on specific project only |
