CRYOSTEM - Cryoconservation during allogeneic hematopoietic Stem cell transplantation

Head :
Peffault De Latour Régis, Service d'hématologie / Greffe
Calmels Boris, Centre de thérapie cellulaire
Fontenille Claire, Centre de thérapie cellulaire
Robert Emilie, Centre de Thérapie Cellulaire

Last update : 09/09/2019 | Version : 2 | ID : 3107

print
Print
xml
XML

Export to XML

Please choose the format :

pdf
PDF
xml
CSV (Excel)

Export to CSV

What sections do you want to export ?

Métadonnées
Identification
General Aspects
Scientific investigator(s) (Contact)
Collaborations
Funding
Governance of the database
Additional contact
Type of database
Database objective
Population type
Dates
Size of the database
Data
Procedures
Promotion
Access
Select all | Invert selection | No selection

Which version do you want to export ?

send
Send
General
Identification
Detailed name Cryoconservation during allogeneic hematopoietic Stem cell transplantation
Sign or acronym CRYOSTEM
CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation CPP Sud-Méditerranée (17/02/2012) : AC-2011-1420, CCTIRS (09/02/2012) : 11-710bis, CNIL
General Aspects
Medical area Cancer research
Hematology
Immunology
Infectious diseases
Pediatrics
Health determinants Iatrogenic
Keywords Graft-versus-host-disease, GvHD, Allogeneic Hematopoietic Stem Cell Transplantation, HSCT, Biobanking network, Complications
Scientific investigator(s) (Contact)
Name of the director Peffault De Latour
Surname Régis
Address 1, avenue Claude Vellefaux 75010 PARIS
Phone + 33 (0)1 42 38 50 73
Email regis.peffaultdelatour@sls.aphp.fr
Unit Service d'hématologie / Greffe
Organization Hôpital Saint Louis
Name of the director Calmels
Surname Boris
Address 232, boulevard Sainte Marguerite 13009 MARSEILLE
Phone + 33 (0)4 91 22 34 41
Email calmelsb@ipc.unicancer.fr
Unit Centre de thérapie cellulaire
Organization Institut Paoli Calmettes
Name of the director Fontenille
Surname Claire
Address 232, boulevard Sainte Marguerite 13009 MARSEILLE
Phone + 33 (0)4 91 22 34 37
Email claire.fontenille@cryostem.org
Unit Centre de thérapie cellulaire
Organization Institut Paoli Calmettes
Name of the director Robert
Surname Emilie
Address 232, bd Sainte Marguerite 13009 Marseille
Phone + 33 (0)4 91 22 34 37
Email emilie.robert@cryostem.org
Unit Centre de Thérapie Cellulaire
Organization Institut Paoli Calmettes
Collaborations
Participation in projects, networks and consortia Yes
Funding
Funding status Mixed
Details ANR "Investissements d'avenir -Grand emprunt"
Governance of the database
Sponsor(s) or organisation(s) responsible CRYOSTEM
Organisation status Private
Presence of scientific or steering committees Yes
Additional contact
Main features
Type of database
Type of database Study databases
Study databases (details) Cohort study
Database recruitment is carried out by an intermediary A selection of health institutions and services
Database recruitment is is made on the basis of: Another treatment or procedure
Database recruitment is carried out as part of an interventional study No
Database objective
Main objective The goal of CryoStem is to create a national, multicenter, prospectie, longitudinal, standardized HSCT human-sample collection (derived from adult and pediatric patients) with the purpose of enabling better characterization and prediction of HSCT complications occurence and outcome, including GvHD.
CryoStem has generated a French network involving all the French transplant units, adult and pediatric and 28 Biological Resources Centres. Only in a network such as this may the full potential be realized of having concrete and effective interactions between scientists with top knowledge in specific areas and physicians. CryoStem fosters interactions among internationally recognized experts in advanced biotechnology (genomics,transcriptomics, proteomics, and flow cytometry).
Altogether, CryoStem provides a structured approach for a range of different research activities, bringing together leading-edge researchers who can access documented biological (CryoStem) and clinical (ProMISe) samples from transplanted patients in order to better characterize and predict HSCT complications.
Inclusion criteria Any patient suffering from a severe blood disease or blood cancer (leukemia, lymphoma, aplastic anemia...) justifying a first HSCT in one of the transplant units of CRYOSTEM network.
Population type
Age Newborns (birth to 28 days)
Infant (28 days to 2 years)
Early childhood (2 to 5 years)
Childhood (6 to 13 years)
Adolescence (13 to 18 years)
Adulthood (19 to 24 years)
Adulthood (25 to 44 years)
Adulthood (45 to 64 years)
Elderly (65 to 79 years)
Great age (80 years and more)
Population covered Sick population
Pathology III - Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
Gender Male
Woman
Geography area National
Detail of the geography area Metropolitan France
Data collection
Dates
Date of first collection (YYYY or MM/YYYY) 2012
Date of last collection (YYYY or MM/YYYY) 2019
Size of the database
Size of the database (number of individuals) [1000-10 000[ individuals
Details of the number of individuals 5 756 patients and 2 375 donors as of August, 31 2019
Data
Database activity Current data collection
Type of data collected Clinical data
Biological data
Clinical data (detail) Direct physical measures
Medical registration
Details of collected clinical data transplant type and date / relapse / graft failure / second transplant / stages and corticoresistance for the acute GvHD / type, classification and evolution of the chronic GvHD
Biological data (detail) Blood samples
Presence of a biobank Yes
Contents of biobank Plasma
Blood cells isolated
Others
Details of biobank content Viable mononuclear cells, plasma, and dried cell pellets
Health parameters studied Health event/morbidity
Health event/mortality
Procedures
Data collection method Data are collected via a unique document filled in as the time of blood samples by the transplant units staff in charge of the patient medical follow-up.
Quality procedure(s) used Sampling and sending / blood samples reception and processing
Participant monitoring Yes
Details on monitoring of participants Duration of CryoStem : 7 years (inclusion : 6 years)
Links to administrative sources No
Promotion and access
Promotion
Description The first publications have been submitted during the summer 2019.
Other information The embargo on the CRYOSTEM samples has ended on 2015/04/15. Since 2015, and as of August, 31 2019, almost 7 000 samples have been provided to 10 research projects on GvHD and HSCT complications.
Access
Presence of document that lists variables and coding procedures Yes
Terms of data access (charter for data provision, format of data, availability delay) Any investigator selected by CRYOSTEM Scientific Committee commits himself to respect the general terms of the current call of projects to access the collection biological resources.
The investigator could access to demographical and clinical information, extracted from the European register of the EBMT (European Society for Blood and Marrow Transplantation), provided via an Excel file made anonymous.
Once selected, CRYOSTEM project managers schedule interviews with the investigators in order to identify and select the samples of interest. The delay of provision depend on the number of the samples waited for.

Access to aggregated data Access on specific project only
Access to individual data Access on specific project only

Partners - FAQ - Contact - Site map - Legal notices - Administration - Updated on December 15 2020 - Version 4.10.05