STANISLAS (Suivi Temporaire Annuel Non Invasif de la Santé des Lorrains Assurés Sociaux) - STANISLAS cohort
Head :
Visvikis-Siest Sophie, UMR INSERM U1122; IGE - PCV
Stathopoulou Maria
Stathopoulou Maria
Last update : 10/25/2017 | Version : 6 | ID : 60111
| General | |
| Identification | |
| Detailed name | STANISLAS cohort |
| Sign or acronym | STANISLAS (Suivi Temporaire Annuel Non Invasif de la Santé des Lorrains Assurés Sociaux) |
| CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation | CNIL n°901090 (27/10/2003) |
| General Aspects | |
| Medical area |
Biology Cardiology General practice |
| Pathology (details) | Environnement |
| Health determinants |
Genetic |
| Keywords | family determinants, indicators, cardiovascular risk, cross-sectional, longitudinal, genetic, environment |
| Scientific investigator(s) (Contact) | |
| Name of the director | Visvikis-Siest |
| Surname | Sophie |
| Address | 30 rue Lionnois - 54000 NANCY |
| Phone | +33 (0)6 07 60 25 69 |
| Sophie.Visvikis-Siest@inserm.fr | |
| Unit | UMR INSERM U1122; IGE - PCV |
| Organization | INSERM - Institut National de la Santé et de la Recherche |
| Name of the director | Stathopoulou |
| Surname | Maria |
| Phone | + 33 3 (0)83 68 21 66 |
| maria.stathopoulou@inserm.fr | |
| Organization | INSERM |
| Collaborations | |
| Participation in projects, networks and consortia |
Yes |
| Details | Consortia VEGF, MAGIC, CHARGE, NCD Risk Factor Collaboration |
| Funding | |
| Funding status |
Mixed |
| Details | Inserm, Université Henri Poincaré (Actuellement Université de Lorraine), Contrat Européen Biomed 2, Région Lorraine, Communauté urbaine du grand Nancy, CNAMTS, ABBOTT, BAYER PHARMA, BECKMAN COULTER, BIOMERIEUX, DADE-BEHRING, DAIICHI, JOHNSON AND JOHNSON (ORTHO-CLINICAL DIAGNOSTICS), KELLOGS, LA PREVIADE, MERCK, RANDOX, ROCHE, SEBIA. |
| Governance of the database | |
| Sponsor(s) or organisation(s) responsible | UMR INSERM U1122, IGE-PCV (Interactions Gène-Environnement en Physiopathologie Cardio-Vasculaire) |
| Organisation status |
Public |
| Additional contact | |
| Main features | |
| Type of database | |
| Type of database |
Study databases |
| Study databases (details) |
Longitudinal study (except cohorts) |
| Database recruitment is carried out by an intermediary |
A population file |
| Database recruitment is carried out as part of an interventional study |
No |
| Additional information regarding sample selection. | Prospective Inclusions ended on: 01/01/1995 |
| Database objective | |
| Main objective | study the family determinants (genetic and environmental) of cardiovascular risk indicators and/or factors by using the model of the nuclear family. The 2 aspects, cross-sectional and longitudinal, are broached through specific designs. |
| Inclusion criteria | Nuclear families, at least 2 children/family, of French origin over 3 generations |
| Population type | |
| Age |
Childhood (6 to 13 years) Adolescence (13 to 18 years) Adulthood (19 to 24 years) Adulthood (25 to 44 years) Adulthood (45 to 64 years) |
| Population covered |
General population |
| Pathology | |
| Gender |
Male Woman |
| Geography area |
Local |
| French regions covered by the database |
Alsace Champagne-Ardenne Lorraine |
| Detail of the geography area | MEURTHE ET MOSELLE SUD, VOSGES |
| Data collection | |
| Dates | |
| Date of first collection (YYYY or MM/YYYY) | 01/1993 |
| Date of last collection (YYYY or MM/YYYY) | 06/2004 |
| Size of the database | |
| Size of the database (number of individuals) |
[1000-10 000[ individuals |
| Details of the number of individuals | 4295 patients / bilan 1 (1006 familles/families)2952 patients / bilan 2 (756 familles/families)359 patients / bilan 3 (99 familles/families) |
| Data | |
| Database activity |
Current data collection |
| Type of data collected |
Clinical data Declarative data Paraclinical data Biological data |
| Clinical data (detail) |
Medical registration |
| Details of collected clinical data | Clinical examination upon inclusion and during follow-up every 5 years.Information gathered during the clinical examination: physical measurements (weight, height, waist size and hip size), blood pressure and heart rate.Electrocardiogram with a Cardionics devicePuberty development in 9 to 18 year olds from the assessment of pubic hair, development of external genitals in boys and breast development and whether or not periods have started in girls.Measurement of the arterial tunica media-intima thickness and arterial rigidity (in a small number of families).Measurement of the body fat percentage and lean body mass using diagnostic scales (in a small number of families). |
| Declarative data (detail) |
Paper self-questionnaire |
| Details of collected declarative data | Clinical examination upon inclusion and during follow-up every 5 years.Information gathered during the clinical examination: physical measurements (weight, height, waist size and hip size), blood pressure and heart rate.Electrocardiogram with a Cardionics devicePuberty development in 9 to 18 year olds from the assessment of pubic hair, development of external genitals in boys and breast development and whether or not periods have started in girls.Measurement of the arterial tunica media-intima thickness and arterial rigidity (in a small number of families).Measurement of the body fat percentage and lean body mass using diagnostic scales (in a small number of families). |
| Paraclinical data (detail) | Height, weight, waist/hip measurement |
| Biological data (detail) | total blood, serum, EDTA plasma, citrate plasma, heparin plasma, urine, PAXgene |
| Presence of a biobank |
Yes |
| Contents of biobank |
DNA DNAc/RNAm Others |
| Details of biobank content | Serum bank, plasma bank, DNA bank, PBMCS FOR RNA, PAXGENE (RNA) PBMCS protein extracts, urines. |
| Health parameters studied |
Health event/morbidity Others |
| Other (detail) | cardiovascular diseases |
| Procedures | |
| Data collection method | Self-questionnaire: entry from a paper questionnaire with double entry Interviews: entry from a paper questionnaire with double entry |
| Quality procedure(s) used | Management of missing data: according to the missing information, either exclusion of the subject or generation of variables |
| Participant monitoring |
Yes |
| Links to administrative sources |
Yes |
| Linked administrative sources (detail) | Preventive Medicine Center, CHU Nancy |
| Promotion and access | |
| Promotion | |
| Link to the document | Publications cohorte STANISLAS version 5-03-2015 - docx.docx |
| Link to the document | http://tinyurl.com/Pubmed-STANISLAS |
| Link to the document | http://tinyurl.com/Hal-STANISLAS |
| Access | |
| Terms of data access (charter for data provision, format of data, availability delay) |
Cohort journal
Possible use of data by academic teams Possible use of data by manufacturers Involvement in a cohort network: BIOBANKING AND BIOMOLECULAR RESOURCES INFRASTRUCTURES (BBMRI) 7th FP |
| Access to aggregated data |
Access on specific project only |
| Access to individual data |
Access on specific project only |
