Last update : 01/01/2019 | Version : 1 | ID : 73086
General | |
Identification | |
Detailed name | Cohort of French Families with Identified MMR Gene Mutation: Assessment of Cancer Risk |
Sign or acronym | ERISCAM |
CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation | CNIL |
General Aspects | |
Medical area |
Cancer research Gastroenterology et hepatology Gynecology/ obstetrics |
Pathology (details) | Lynch syndrome |
Health determinants |
Genetic |
Keywords | Lynch syndrome, gynaecology, MMR genes, cumulative risk, MLH1, MSH2, MSH6, colorectal, cancer, genetic, mutation |
Scientific investigator(s) (Contact) | |
Name of the director | Lasset |
Surname | Christine |
Phone | +33 (0)4 78 78 28 27 |
christine.lasset@lyon.unicancer.fr | |
Unit | Prevention and genetics epidemiology |
Organization | CNRS |
Name of the director | Bonadona |
Surname | Valérie |
Phone | 33 (0)4 78 78 27 66 |
valerie.bonadona@lyon.unicancer.fr | |
Organization | CNRS |
Name of the director | Bonaiti-Pellie |
Surname | Catherine |
Phone | 33 (0)1 45 59 53 61 |
catherine.bonaiti@inserm.fr | |
Unit | Genetics epidemiology and human population structures |
Organization | Inserm |
Name of the director | Olschwang |
Surname | Sylviane |
Phone | +33 (0) 491 324 884 |
sylviane.olschwang@inserm.fr | |
Unit | Medical Genetics and Functional Genomics |
Organization | Inserm |
Collaborations | |
Funding | |
Funding status |
Private |
Details | Fondation de France |
Governance of the database | |
Sponsor(s) or organisation(s) responsible | Centre Léon Bérard |
Organisation status |
Private |
Additional contact | |
Main features | |
Type of database | |
Type of database |
Study databases |
Study databases (details) |
Cohort study |
Database recruitment is carried out by an intermediary |
An administrative base or a register |
Database recruitment is carried out as part of an interventional study |
No |
Database objective | |
Main objective | The aim is to reliably and accurately determine the risks of different tumours in subjects with MMR gene mutations. |
Inclusion criteria | French families with an identified MMR gene mutation recruited throughout 40 cancer genetic consultation centres participating in the study; all members of the Cancer and Genetics Network. |
Population type | |
Age |
Adulthood (19 to 24 years) Adulthood (25 to 44 years) Adulthood (45 to 64 years) Elderly (65 to 79 years) Great age (80 years and more) |
Population covered |
Sick population |
Gender |
Male Woman |
Geography area |
National |
Detail of the geography area | France |
Data collection | |
Dates | |
Date of first collection (YYYY or MM/YYYY) | 2007 |
Date of last collection (YYYY or MM/YYYY) | 2009 |
Size of the database | |
Size of the database (number of individuals) |
[1000-10 000[ individuals |
Details of the number of individuals | 537 families (248: MSH1 mutation, 256 MSH2 mutation, 33 MSH6 mutation). 2,622 patients |
Data | |
Database activity |
Data collection completed |
Type of data collected |
Clinical data Declarative data |
Clinical data (detail) |
Direct physical measures |
Details of collected clinical data | Sex; age; age at last follow-up; cancer history (location, age at diagnosis, death); mutation status; colonoscopic surveillance method; colorectal or gynaecological surgery |
Declarative data (detail) |
Face to face interview |
Details of collected declarative data | Information not available, even if medical record exists. |
Presence of a biobank |
No |
Procedures | |
Participant monitoring |
Yes |
Details on monitoring of participants | 2006, 2007, 2009 |
Links to administrative sources |
Yes |
Promotion and access | |
Promotion | |
Link to the document | http://www.hnpcc-lynch.com/?p=515 |
Link to the document | http://tinyurl.com/PUBMED-ERISCAM |
Link to the document | http://tinyurl.com/HAL-ERISCAM |
Access | |
Terms of data access (charter for data provision, format of data, availability delay) | Contact the scientist in charge. |
Access to aggregated data |
Access on specific project only |
Access to individual data |
Access on specific project only |
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