CODEX - ANRS CO21 Cohort

Head :
Lambotte Olivier

Last update : 02/17/2020 | Version : 1 | ID : 73422

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Métadonnées
Identification
General Aspects
Scientific investigator(s) (Contact)
Collaborations
Funding
Governance of the database
Additional contact
Type of database
Database objective
Population type
Dates
Size of the database
Data
Procedures
Promotion
Access
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General
Identification
Detailed name ANRS CO21 Cohort
Sign or acronym CODEX
CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation CPP 11-033
General Aspects
Medical area Infectious diseases
Health determinants Genetic
Healthcare system and access to health care services
Lifestyle and behavior
Social and psychosocial factors
Keywords HIV Controllers, HIV infection
Scientific investigator(s) (Contact)
Name of the director Lambotte
Surname Olivier
Address Hôpital de Bicêtre, Service de Médecine Interne, 78 rue du Général Leclerc, Le Kremlin-Bicêtre 94276
Phone 0145212783
Email olivier.lambotte@aphp.fr
Organization AP-HP
Collaborations
Participation in projects, networks and consortia Yes
Funding
Funding status Public
Details ANRS
Governance of the database
Sponsor(s) or organisation(s) responsible ANRS
Organisation status Public
Presence of scientific or steering committees Yes
Additional contact
Name of the contact Boufassa
Surname Faroudy
Address INSERM CESP U1018, Hôpital de Bicêtre, Service de Médecine Interne, 82 rue du Général Leclerc, Le Kremlin-Bicêtre 94276
Phone 0145212365
Email faroudy.boufassa@inserm.fr
Unit Epidémiologie
Organization INSERM
Main features
Type of database
Type of database Study databases
Study databases (details) Cohort study
Database recruitment is carried out by an intermediary A selection of health institutions and services
Database recruitment is is made on the basis of: Another treatment or procedure
Database recruitment is carried out as part of an interventional study No
Database objective
Main objective In HIV-1 positive patients who have been asymptomatic for at least 5 years after HIV infection in the absence of antiretroviral therapy, whether they meet the definitions of Long time non-Progressors and/or HIV Controllers and in patients on antiretroviral therapy and in "control after discontinuation of antiretroviral therapy", study their clinical and immuno-virological course and define the virus and host parameters associated with non-progression of infection.
Inclusion criteria LTNP subjects: Long Term Non Progressors: HIV-1 positive subjects for at least 8 years with a CD4+ lymphocyte count greater than 600/mm3 and stable or increasing (positive or zero slope) on at least 3 consecutive tests performed in the last 5 years regardless of viral load in the absence of antiretroviral treatment.
HIC (HIV Controllers)" subjects: HIV-1 positive subjects for at least 5 years, asymptomatic, with the last 5 consecutive plasma HIV RNA viral loads < 400 copies/mL whatever the CD4+ level in the absence of antiretroviral treatment.
LTNP-HIC" subjects: subjects meeting the double definition of LTNP and HIC, i.e. HIV-1 subjects who have been HIV-positive for at least 8 years and CD4+ lymphocyte count greater than 600/mm3 with a stable or increasing level (positive or zero slope) on at least 3 consecutive examinations carried out over the last 5 years and with the last 5 consecutive plasma HIV-RNA viral loads < 400 copies/mL.
Subjects in "post-treatment control" (or post-treatment controllers, PTC): Subjects who had a plasma HIV-RNA viral load > 2000 copies/mL prior to initiation of antiretroviral therapy in either primary or chronic phase and who were maintained on antiretroviral therapy for at least 12 months; in whom, after antiretroviral therapy was discontinued, the viral load remained < 400 copies/mL for more than 12 months with the exception of one blip (plasma viral load above 400 copies/mL) surrounded by two viral loads < 400 copies/mL. The last plasma viral load at the time of inclusion should, in all cases, be < 400 copies/mL.
Population type
Age Adulthood (19 to 24 years)
Adulthood (25 to 44 years)
Adulthood (45 to 64 years)
Elderly (65 to 79 years)
Population covered Sick population
Pathology B20-B24 - Human immunodeficiency virus [HIV] disease
Gender Male
Woman
Other
Geography area National
Detail of the geography area Fance and DOM-TOM
Data collection
Dates
Date of first collection (YYYY or MM/YYYY) 2014
Size of the database
Size of the database (number of individuals) < 500 individuals
Details of the number of individuals 346
Data
Database activity Current data collection
Type of data collected Clinical data
Biological data
Clinical data (detail) Direct physical measures
Medical registration
Presence of a biobank Yes
Contents of biobank Whole blood
Serum
Plasma
Blood cells isolated
Health parameters studied Health event/morbidity
Health event/mortality
Quality of life/health perception
Procedures
Participant monitoring Yes
Monitoring procedures Monitoring by contact with the referring doctor
Links to administrative sources No
Promotion and access
Promotion
Access
Terms of data access (charter for data provision, format of data, availability delay) Availability of data after validation of a research project by the Scientific Council of the cohort. Data format on tables (SAS, Excel, Stata).
Access to aggregated data Access on specific project only
Access to individual data Access on specific project only

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