ARDCO - Cohort on Screening Programme for Asbestos-Related Diseases
Head :
Pairon Jean-Claude, INSERM UNITÉ 955 - GEIC2O INSERM
Last update : 10/13/2020 | Version : 5 | ID : 60027
| General | |
| Identification | |
| Detailed name | Cohort on Screening Programme for Asbestos-Related Diseases |
| Sign or acronym | ARDCO |
| CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation | CNIL 908001 (16/04/08), amendement 10/09/10, 22/05/2015, 17/06/2016, 05/07/2017 ; CPP 1946 (11/02/02) |
| General Aspects | |
| Medical area |
Cancer research Occupational Medicine |
| Health determinants |
Occupation |
| Keywords | long-duration disease (LDD), pleural plaques, asbestosis, medical usage, chest CT scan, anxiety, lung cancer, mesothelioma, colon cancer, Health episodes, treatment, mortality, asbestos |
| Scientific investigator(s) (Contact) | |
| Name of the director | Pairon |
| Surname | Jean-Claude |
| Address | 94010 CRÉTEIL |
| Phone | + 33 (0)1 57 02 20 90 |
| jc.pairon@chicreteil.fr | |
| Unit | INSERM UNITÉ 955 - GEIC2O INSERM |
| Organization | INSTITUT INTER-UNIVERSITAIRE DE MEDECINE DU TRAVAIL DE PARIS ILE DE FRANCE |
| Collaborations | |
| Participation in projects, networks and consortia |
Yes |
| Funding | |
| Funding status |
Public |
| Details | CNAM (CRAMIF), ANSES |
| Governance of the database | |
| Sponsor(s) or organisation(s) responsible | Institut inter-universitaire de médecine du travail de Paris - Ile de France (IIMTPIF) |
| Organisation status |
Private |
| Presence of scientific or steering committees |
Yes |
| Additional contact | |
| Main features | |
| Type of database | |
| Type of database |
Study databases |
| Study databases (details) |
Cohort study |
| Database recruitment is carried out by an intermediary |
A population file |
| Database recruitment is carried out as part of an interventional study |
No |
| Additional information regarding sample selection. | Prospective Other bodies active in creating this cohort: CPAM, IIMTPIF, INSERM, University (Bordeaux), Social Security (ERSM RHONE ALPES) Inclusion cut-off date: 01/12/2005 |
| Database objective | |
| Main objective | 1 - To evaluate the incidence of cancer mortality (including lung and pleura cancers) in the ARDCO cohort based on work calendar and benign asbestos-related diseases (asbestosis, pleural plaques). 2 - Evaluation of the contribution of CT examinations, thoughts on examination periodicity. 3 - To assess the psychological impact of post-occupational medical surveillance of individuals exposed to asbestos 4 - To evaluate the role of co-exposures to other carcinogens with asbestos pollution in the risk of developing cancer 5 - To contribute to defining the populations at risk of lung cancer 6 - To contribute defining optimal methods for monitoring populations previously exposed to asbestos |
| Inclusion criteria | Subjects affiliated with a general social security scheme, retired (or a few inactive subjects), exposed to asbestos professionally, with different age limits according to all 4 regions. |
| Population type | |
| Age |
Adulthood (45 to 64 years) Elderly (65 to 79 years) Great age (80 years and more) |
| Population covered |
General population |
| Pathology | |
| Gender |
Male Woman |
| Geography area |
Local |
| French regions covered by the database |
Aquitaine Limousin Poitou-Charentes Auvergne Rhône-Alpes Normandie |
| Detail of the geography area | Multicentric cohort throughout France (4 regions): Aquitaine, Rhônes-Alpes, Upper and Lower Normandy |
| Data collection | |
| Dates | |
| Date of first collection (YYYY or MM/YYYY) | 10/2002 |
| Date of last collection (YYYY or MM/YYYY) | 2021 |
| Size of the database | |
| Size of the database (number of individuals) |
[10 000-20 000[ individuals |
| Details of the number of individuals | 16000 |
| Data | |
| Database activity |
Current data collection |
| Type of data collected |
Clinical data Declarative data Paraclinical data |
| Clinical data (detail) |
Direct physical measures Medical registration |
| Declarative data (detail) |
Paper self-questionnaire |
| Paraclinical data (detail) | Imaging (chest CT)2002-2005- lung function test by a pulmonologist (initial assessment) for 5825 patients, then chest CT for 2350 patients in 2011-2012 and chest CT for 1339 patients in in 2018-2019 |
| Presence of a biobank |
No |
| Health parameters studied |
Health event/morbidity Health event/mortality Health care consumption and services |
| Care consumption (detail) |
Hospitalization |
| Procedures | |
| Data collection method | Self-administered questionnaire: input from a paper questionnaire or optical input (Daptascan) - Clinical examination data collected by treating physician at baseline: input from a paper questionnaire - chest CT: optical reading from a standardised review scale |
| Participant monitoring |
Yes |
| Monitoring procedures |
Monitoring by contact with the participant (mail, e-mail, telephone etc.) |
| Details on monitoring of participants | Since 2002. Programm in progress in 2020 |
| Links to administrative sources |
Yes |
| Linked administrative sources (detail) | CépiDC, Health insurance databases, Cancer registries for départements involved |
| Promotion and access | |
| Promotion | |
| Link to the document | http://tinyurl.com/HAL-ARDCO |
| Description | List of publications in HAL |
| Link to the document | http://tinyurl.com/Pubmed-ARDCO |
| Description | List of publications in Pubmed |
| Access | |
| Terms of data access (charter for data provision, format of data, availability delay) | Data may be used by academic teams. Currently no access but no objection to opening the database to academic teams. All data access requests according to agreement by the ARDCO project National Science Council Data may not be used by industrial teams. |
| Access to aggregated data |
Access on specific project only |
| Access to individual data |
Access on specific project only |
