ANRS CO15 ALT - Cohort of Long-Term Asymptomatic Subjects Infected with HIV
Head :
Autran Brigitte, LABORATOIRE D'IMMUNOLOGIE CELLULAIRE ET ET TISSULAIRE SERVICE DU PR DEBRÉ INSERM UMR-S 945 IMMUNITÉ ET INFECTION, IFR113
Last update : 07/07/2015 | Version : 2 | ID : 60151
| General | |
| Identification | |
| Detailed name | Cohort of Long-Term Asymptomatic Subjects Infected with HIV |
| Sign or acronym | ANRS CO15 ALT |
| CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation | CNIL: 26/05/1994 |
| General Aspects | |
| Medical area |
Immunology Infectious diseases |
| Health determinants |
Genetic |
| Keywords | follow-up, Health episodes, infection |
| Scientific investigator(s) (Contact) | |
| Name of the director | Autran |
| Surname | Brigitte |
| Address | 75013 PARIS |
| brigitte.autran@psl.ap-hop-paris.fr | |
| Unit | LABORATOIRE D'IMMUNOLOGIE CELLULAIRE ET ET TISSULAIRE SERVICE DU PR DEBRÉ INSERM UMR-S 945 IMMUNITÉ ET INFECTION, IFR113 |
| Organization | Agence Nationale de Recherches sur le Sida et les hépatites virales |
| Collaborations | |
| Participation in projects, networks and consortia |
Yes |
| Funding | |
| Funding status |
Public |
| Details | ANRS |
| Governance of the database | |
| Sponsor(s) or organisation(s) responsible | Agence Nationale de Recherches sur le Sida et les hépatites virales (ANRS) |
| Organisation status |
Public |
| Additional contact | |
| Main features | |
| Type of database | |
| Type of database |
Study databases |
| Study databases (details) |
Cohort study |
| Database recruitment is carried out by an intermediary |
A selection of health institutions and services |
| Database recruitment is carried out as part of an interventional study |
No |
| Additional information regarding sample selection. | Prospective Inclusion cut-off date not determined |
| Database objective | |
| Main objective | General objective: To define virus and host parameters associated with asymptomatic clinical status for 8 years or more following HIV infection. Secondary objective: HIV molecular characterisation, viral co-infections (HCV, CMV, HHV-8 ...); genetics and host immune response: CD4 T and anti-HIV CD8; anti-HIV antibodies and neutralising Ac; innate immunity, immune response to co-infections. |
| Inclusion criteria | Men or women over 18 years old, homosexual or bisexual, withdrawing addicts, individuals who have undergone transfusions or haemophiliacs, seropositive for at least 8 years, receiving no antiretroviral treatment, (stage II) or (stage III), with a CD4 count above 20% and 600/mm3 (more or less 10%) with a stable or increasing count over a minimum of 3 examinations during the last 5 years, who have given signed and clear consent. |
| Population type | |
| Age |
Adulthood (19 to 24 years) Adulthood (25 to 44 years) Adulthood (45 to 64 years) Elderly (65 to 79 years) Great age (80 years and more) |
| Population covered |
Sick population |
| Gender |
Male Woman |
| Geography area |
National |
| Detail of the geography area | Multicentric cohort throughout France (14 centres) |
| Data collection | |
| Dates | |
| Date of first collection (YYYY or MM/YYYY) | 10/1994 |
| Size of the database | |
| Size of the database (number of individuals) |
< 500 individuals |
| Details of the number of individuals | 71 |
| Data | |
| Database activity |
Data collection completed |
| Type of data collected |
Clinical data Biological data |
| Clinical data (detail) |
Direct physical measures Medical registration |
| Biological data (detail) | Type of samples taken: biological profile, samples for immunological, genetic and virological analyses |
| Presence of a biobank |
Yes |
| Contents of biobank |
Plasma Cell lines |
| Details of biobank content | Plasma bank, cell bank |
| Health parameters studied |
Health event/morbidity Health event/mortality |
| Procedures | |
| Participant monitoring |
Yes |
| Details on monitoring of participants | (Indefinite duration) |
| Links to administrative sources |
No |
| Promotion and access | |
| Promotion | |
| Link to the document | http://www.ncbi.nlm.nih.gov/pubmed/?term=ANRS+CO15 |
| Description | List of publications in Pubmed |
| Access | |
| Terms of data access (charter for data provision, format of data, availability delay) | Data may be used by academic teams To be decided if data may be used by industrial teams. |
| Access to aggregated data |
Access on specific project only |
| Access to individual data |
Access on specific project only |
