OFELY - Characterisation of Age-Related Bone Loss In Women
Head :
Delmas Pierre, U831
Last update : 07/21/2015 | Version : 2 | ID : 60069
| General | |
| Identification | |
| Detailed name | Characterisation of Age-Related Bone Loss In Women |
| Sign or acronym | OFELY |
| CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation | Accord CNIL |
| General Aspects | |
| Medical area |
Endocrinology and metabolism Geriatrics Radiology and medical imaging |
| Health determinants |
Climate Social and psychosocial factors |
| Keywords | osteoporosis, clinical risk factors, falls, activity, physical, muscular strength, menopausal status, anthropometric, family history, osteoarthritis, Health episodes, fractures, treatment |
| Scientific investigator(s) (Contact) | |
| Name of the director | Delmas |
| Surname | Pierre |
| delmas@lyon.inserm.fr | |
| Unit | U831 |
| Organization | Institut National de la Santé et de la Recherche |
| Collaborations | |
| Participation in projects, networks and consortia |
Yes |
| Funding | |
| Funding status |
Mixed |
| Details | PROA MERCK SHARP & DOHME (MSD), PREVENTION DES MALADIES OSSEUSES (PMO), AMGEN |
| Governance of the database | |
| Sponsor(s) or organisation(s) responsible | Institut National de la Santé et de la Recherche Médicale |
| Organisation status |
Public |
| Additional contact | |
| Main features | |
| Type of database | |
| Type of database |
Study databases |
| Study databases (details) |
Cohort study |
| Database recruitment is carried out by an intermediary |
A population file |
| Database recruitment is carried out as part of an interventional study |
No |
| Additional information regarding sample selection. | Inclusion method: Prospective |
| Database objective | |
| Main objective | General objective: Prospective evaluation characterising age-related bone loss normal women at different skeletal sites. Secondary objectives are: - to identify the clinical, biochemical and hormonal determinants of bone loss and to predict the rate of bone loss using biochemical markers. To investigate fracture determinants in menopausal women (bone loss, clinical, biochemical and hormonal factors as well as bone microarchitecture) - to study osteoarthritis: the relationship between osteoarthritis and osteoporosis, osteoarthritis and specific cartilage markers and longitudinal osteoarthritic development in the knees for the entire cohort |
| Inclusion criteria | Women between 30 and 90 years old, registered with the MGEN section in Rhône, living in Rhône and the surrounding départements. |
| Population type | |
| Age |
Adulthood (25 to 44 years) Adulthood (45 to 64 years) Elderly (65 to 79 years) |
| Population covered |
General population |
| Gender |
Woman |
| Geography area |
Departmental |
| French regions covered by the database |
Auvergne Rhône-Alpes |
| Detail of the geography area | Lyon region and surrounding départements |
| Data collection | |
| Dates | |
| Date of first collection (YYYY or MM/YYYY) | 1992 |
| Date of last collection (YYYY or MM/YYYY) | 12/2009 |
| Size of the database | |
| Size of the database (number of individuals) |
[1000-10 000[ individuals |
| Details of the number of individuals | 1207 |
| Data | |
| Database activity |
Current data collection |
| Type of data collected |
Clinical data Declarative data Paraclinical data Biological data |
| Clinical data (detail) |
Direct physical measures Medical registration |
| Declarative data (detail) |
Paper self-questionnaire |
| Paraclinical data (detail) | Imaging |
| Biological data (detail) | Type of samples taken: Blood, urine |
| Presence of a biobank |
Yes |
| Contents of biobank |
Serum Plasma Fluids (saliva, urine, amniotic fluid, …) DNA |
| Details of biobank content | Serum bank, Plasma bank, DNA bank and at EACH SAMPLE: URINE - 1ST AND 2ND MICTURITION AND AT 24 HOURS (FOLLOW-UP 5) |
| Health parameters studied |
Health event/morbidity Health event/mortality |
| Procedures | |
| Data collection method | Self-administered questionnaire: Input from a paper questionnaire (Manual input) with double data entry Clinical examinations: Handwritten (Manual input) |
| Participant monitoring |
Yes |
| Links to administrative sources |
No |
| Promotion and access | |
| Promotion | |
| Link to the document | http://tinyurl.com/HAL-OFELY |
| Description | List of publications in HAL |
| Link to the document | http://www.ncbi.nlm.nih.gov/pubmed/?term=OFELY+OR+Os+des+Femmes+de+Lyon |
| Description | List of publications in Pubmed |
| Access | |
| Terms of data access (charter for data provision, format of data, availability delay) | Data may be used by academic teams Data may be used by industrial teams |
| Access to aggregated data |
Access on specific project only |
| Access to individual data |
Access on specific project only |
