ESTELLE - Case-control Study on Childhood Embryonal Tumours, Lymphoma and Leukaemia
Head :
Clavel Jacqueline, Épidémiologie environnementale des cancers
Rudant Jérémie, Épidémiologie environnementale des cancers
Rudant Jérémie, Épidémiologie environnementale des cancers
Last update : 07/04/2014 | Version : 1 | ID : 6607
| General | |
| Identification | |
| Detailed name | Case-control Study on Childhood Embryonal Tumours, Lymphoma and Leukaemia |
| Sign or acronym | ESTELLE |
| CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation | CNIL N° 908283 (juin 2009); Ile de France IV, 2008/12NICB (hors RBM) |
| General Aspects | |
| Medical area |
Cancer research Hematology Immunology |
| Health determinants |
Genetic |
| Others (details) | Cancers, embryonal tumour, lymphoma, leukaemia |
| Keywords | Perinatal risk, infection risk, environment, genetics, child |
| Scientific investigator(s) (Contact) | |
| Name of the director | Clavel |
| Surname | Jacqueline |
| Address | 16, Avenue Paul Vaillant-Couturier 94807 VILLEJUIF |
| Phone | +33 (0)1 45 59 50 38 |
| jacqueline.clavel@inserm.fr | |
| Unit | Épidémiologie environnementale des cancers |
| Organization | Institut National de la Santé et de la Recherche |
| Name of the director | Rudant |
| Surname | Jérémie |
| Address | 16, Avenue Paul Vaillant-Couturier 94807 VILLEJUIF |
| Phone | (+33) 01 45 59 50 29 |
| jeremie.rudant@inserm.fr | |
| Unit | Épidémiologie environnementale des cancers |
| Organization | Institut National de la Santé et de la Recherche |
| Collaborations | |
| Participation in projects, networks and consortia |
Yes |
| Funding | |
| Funding status |
Public |
| Details | - Institut National Du Cancer - Ligue Nationale contre le Cancer - Enfants et Santé - Direction de l'hospitalisation et de l'organisation des soins |
| Governance of the database | |
| Sponsor(s) or organisation(s) responsible | Institut National de la Santé et de la Recherche Médicale |
| Organisation status |
Public |
| Additional contact | |
| Main features | |
| Type of database | |
| Type of database |
Study databases |
| Study databases (details) |
Case control study |
| Database recruitment is carried out by an intermediary |
A selection of health institutions and services |
| Database recruitment is carried out as part of an interventional study |
No |
| Additional information regarding sample selection. | Recruited individuals under 15 years of age in 2010-2011 with leukaemia, lymphoma, brain tumour, neuroblastoma, nephroblastoma or hepatoblastoma. Case-controls: individuals recruited from the general population who are the same age as cases subjects on average |
| Database objective | |
| Main objective | To investigate the influence of the following on childhood cancer risk: pregnancy outcome, child's characteristics at birth, child's environment in utero or during childhood, parents' profession and lifestyle, successive domicile communities, family history of cancer, birth defects, or autoimmune diseases. To identify genetic predispositions capable of modulating the function of these factors, including polymorphisms in genes involved in the transport and metabolism of xenobiotics, DNA repair, immune response, or in embryonic development and cell differentiation. To investigate the interactions between these polymorphisms and environmental factors. |
| Inclusion criteria | - Men or women - under 15 years old at enrolment |
| Population type | |
| Age |
Newborns (birth to 28 days) Infant (28 days to 2 years) Early childhood (2 to 5 years) Childhood (6 to 13 years) Adolescence (13 to 18 years) |
| Population covered |
Sick population |
| Gender |
Male Woman |
| Geography area |
National |
| Detail of the geography area | France |
| Data collection | |
| Dates | |
| Date of first collection (YYYY or MM/YYYY) | 2010 |
| Date of last collection (YYYY or MM/YYYY) | 2011 |
| Size of the database | |
| Size of the database (number of individuals) |
[1000-10 000[ individuals |
| Details of the number of individuals | 3237: - 1814 cas/cases - 1423 témoins/controls |
| Data | |
| Database activity |
Data collection completed |
| Type of data collected |
Declarative data Biological data |
| Declarative data (detail) |
Phone interview |
| Biological data (detail) | - blood collection - saliva sample |
| Presence of a biobank |
Yes |
| Contents of biobank |
DNA |
| Details of biobank content | Blood sample and saliva sample |
| Health parameters studied |
Health event/morbidity |
| Procedures | |
| Data collection method | Once gathered, data from interviews and biological data will be rendered anonymous. |
| Participant monitoring |
Yes |
| Links to administrative sources |
No |
| Promotion and access | |
| Promotion | |
| Link to the document | https://clic.berkeley.edu/ |
| Link to the document | http://www.ncbi.nlm.nih.gov/pubmed/?term |
| Access | |
| Terms of data access (charter for data provision, format of data, availability delay) | To be defined |
| Access to aggregated data |
Access on specific project only |
| Access to individual data |
Access on specific project only |
