GEOCAP - Case-Control Study Based on Childhood Cancer Geolocalisation
Head :
CLAVEL Jacqueline, UMR-S 1153, CRESS, Team 7 / Epidemiology of childhood and adolescent cancers
GOUJON Stéphanie, UMR-S 1153, CRESS, Team 7 / Epidemiology of childhood and adolescent cancers
GOUJON Stéphanie, UMR-S 1153, CRESS, Team 7 / Epidemiology of childhood and adolescent cancers
Last update : 01/19/2022 | Version : 1 | ID : 6722
| General | |
| Identification | |
| Detailed name | Case-Control Study Based on Childhood Cancer Geolocalisation |
| Sign or acronym | GEOCAP |
| CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation | N°CNIL: 998198, 900183 |
| General Aspects | |
| Medical area |
Cancer research Hematology Immunology Pediatrics |
| Study in connection with Covid-19 |
No |
| Health determinants |
Geography Pollution Social and psychosocial factors Others (specify) |
| Others (details) | Cancer, brain tumour, leukaemia |
| Keywords | Environmental exposure, risk, incidence, child |
| Scientific investigator(s) (Contact) | |
| Name of the director | CLAVEL |
| Surname | Jacqueline |
| Address | 16, Avenue Paul Vaillant-Couturier 94807 VILLEJUIF |
| Phone | +33 (0)1 45 59 50 37 |
| jacqueline.clavel@inserm.fr | |
| Unit | UMR-S 1153, CRESS, Team 7 / Epidemiology of childhood and adolescent cancers |
| Organization | INSERM |
| Name of the director | GOUJON |
| Surname | Stéphanie |
| Address | 16, Avenue Paul Vaillant-Couturier 94807 VILLEJUIF |
| Phone | +33 (0)1 45 59 50 37 |
| Stephanie.goujon@inserm.fr | |
| Unit | UMR-S 1153, CRESS, Team 7 / Epidemiology of childhood and adolescent cancers |
| Organization | INSERM |
| Collaborations | |
| Participation in projects, networks and consortia |
Yes |
| Funding | |
| Funding status |
Mixed |
| Details | - EDF- Fondation Pfizer- Institut national de Veille Sanitaire- Agence Nationale de la Recherche- Agence nationale de sécurité sanitaire de l'alimentation- Fondation ARC pour la recherche sur le cancer- Institut National Du Cancer |
| Governance of the database | |
| Sponsor(s) or organisation(s) responsible | Institut national de la santé et de la recherche médicale |
| Organisation status |
Public |
| Presence of scientific or steering committees |
No |
| Additional contact | |
| Main features | |
| Type of database | |
| Type of database |
Study databases |
| Study databases (details) |
Case control study |
| Database recruitment is carried out by an intermediary |
A population file An administrative base or a register |
| Database recruitment is is made on the basis of: |
Another treatment or procedure |
| Database recruitment is carried out as part of an interventional study |
No |
| Additional information regarding sample selection. | Includes all cancer cases for children under 15 years old who have been diagnosed with cancer or benign brain tumour since 2002, living in mainland France at the time of diagnosis.Includes all child case-controls under 15 years old from the general population, represented by a sample of 5,000 child addresses per year, created by INSEE on tax record database. |
| Database objective | |
| Main objective | To study the influence of several environmental exposures on the risk of childhood cancer - proximity to power lines and exposure to electric and magnetic fields at extremely low frequency - proximity to traffic lanes and environmental exposure to benzene and other pollutants - exposure to living spaces with natural ionising radiation, especially radon and gamma radiation - proximity to industrial sites |
| Inclusion criteria | - Men or women - under 15 years old |
| Population type | |
| Age |
Newborns (birth to 28 days) Infant (28 days to 2 years) Early childhood (2 to 5 years) Childhood (6 to 13 years) Adolescence (13 to 18 years) |
| Population covered |
General population |
| Pathology | |
| Gender |
Male Woman |
| Geography area |
National |
| Detail of the geography area | France |
| Data collection | |
| Dates | |
| Date of first collection (YYYY or MM/YYYY) | 2002 |
| Size of the database | |
| Size of the database (number of individuals) |
Greater than 20 000 individuals |
| Details of the number of individuals | 6700:- 1700 cancers (470 leucémies/leukemias)/cases- 5000 témoins/controls |
| Data | |
| Database activity |
Current data collection |
| Type of data collected |
Clinical data Biological data Administrative data |
| Clinical data (detail) |
Direct physical measures |
| Biological data (detail) | DNA |
| Presence of a biobank |
No |
| Health parameters studied |
Health event/morbidity Others |
| Other (detail) | Radiation doses due to gaseous discharges from nuclear power plants: IRSN/DRPH/SER Data on natural ionising radiation sources: IRSN/PRP-DGE/SEDRAN/BRN Localisation of power lines: RTE |
| Procedures | |
| Data collection method | Data related to child exposure are estimated from their home address geocoded accurately. |
| Participant monitoring |
No |
| Followed pathology | |
| Links to administrative sources |
No |
| Promotion and access | |
| Promotion | |
| Link to the document | http://onlinelibrary.wiley.com/doi/10.1002/ijc.27425/pdf |
| Link to the document | http://www.nature.com/bjc/journal/v108/n9/full/bjc2013128a.html?foxtrotcallback=true |
| Link to the document | https://ehp.niehs.nih.gov/EHP296/ |
| Link to the document | http://onlinelibrary.wiley.com/doi/10.1111/ppe.12313/full |
| Link to the document | https://academic.oup.com/aje/article/182/8/685/207208 |
| Link to the document | https://www.sciencedirect.com/science/article/pii/S0265931X17309980?via%3Dihub |
| Access | |
| Terms of data access (charter for data provision, format of data, availability delay) | To be defined |
| Access to aggregated data |
Access on specific project only |
| Access to individual data |
Access on specific project only |
