CECILE - Breast Cancer: Epidemiological Study on Environment in Côte d’Or and Ille-et-Vilaine 
Head :
Guénel Pascal, CESP - UMR S 1018
Epidémiologie environnementale des cancers de l'adulte
Last update : 01/01/2018 | Version : 1 | ID : 6495
| General | |
| Identification | |
| Detailed name | Breast Cancer: Epidemiological Study on Environment in Côte d’Or and Ille-et-Vilaine |
| Sign or acronym | CECILE |
| CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation | CNIL n°04-1230 (2004), CPP (CCPPRB Kremlin-Bicêtre) n°04-53 (ref 04-21) |
| General Aspects | |
| Medical area |
Cancer research |
| Health determinants |
Genetic Geography Nutrition Occupation Pollution |
| Others (details) | Breast cancer |
| Keywords | Risk factors, exposure, environment |
| Scientific investigator(s) (Contact) | |
| Name of the director | Guénel |
| Surname | Pascal |
| Address | 16 avenue Paul Vaillant-Couturier, 94807 VILLEJUIF |
| Phone | +33 (0)1 45 59 50 27 |
| pascal.guenel@inserm.fr | |
| Unit |
CESP - UMR S 1018 Epidémiologie environnementale des cancers de l'adulte |
| Organization | Institut National de la Santé et de la Recherche |
| Collaborations | |
| Funding | |
| Funding status |
Mixed |
| Details | - Institut National Du Cancer - Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail - Ligue Nationale contre le Cancer, - Agence Nationale de la Recherche - Fondation de France |
| Governance of the database | |
| Sponsor(s) or organisation(s) responsible | Institut National de la Santé et de la Recherche Médicale |
| Organisation status |
Public |
| Additional contact | |
| Main features | |
| Type of database | |
| Type of database |
Study databases |
| Study databases (details) |
Case control study |
| Database recruitment is carried out by an intermediary |
A selection of health institutions and services |
| Database recruitment is carried out as part of an interventional study |
No |
| Additional information regarding sample selection. | Cases were identified by main cancer treatment centres in the Côte d'Or and Ille-et-Vilaine départements. Case-controls are women matched according to cancer case age and are selected in order to form a representative sample of women of the same age in each département. |
| Database objective | |
| Main objective | To highlight environmental risk factors for breast cancer and investigate the role of lifestyle or exposure to harmful conditions. To identify genetic susceptibility factors and study gene–environment interaction. |
| Inclusion criteria | - women aged 75 years old and under |
| Population type | |
| Age |
Adulthood (19 to 24 years) Adulthood (25 to 44 years) Adulthood (45 to 64 years) Elderly (65 to 79 years) |
| Population covered |
General population |
| Gender |
Woman |
| Geography area |
Departmental |
| French regions covered by the database |
Bourgogne Franche-Comté Bretagne |
| Detail of the geography area | Côte d'Or and Ille-et-Vilaine |
| Data collection | |
| Dates | |
| Date of first collection (YYYY or MM/YYYY) | 2005 |
| Date of last collection (YYYY or MM/YYYY) | 2008 |
| Size of the database | |
| Size of the database (number of individuals) |
[1000-10 000[ individuals |
| Details of the number of individuals | 2500 sujets - 1200 cas / cases - 1300 témoins / controls |
| Data | |
| Database activity |
Data collection completed |
| Type of data collected |
Clinical data Declarative data Biological data |
| Clinical data (detail) |
Direct physical measures |
| Declarative data (detail) |
Face to face interview |
| Biological data (detail) | Anatomopathological classification of tumour for DNA bank and serum bank |
| Presence of a biobank |
Yes |
| Contents of biobank |
Whole blood Serum Buccal cells DNA |
| Details of biobank content | DNA bank and serum bank |
| Health parameters studied |
Health event/morbidity Health care consumption and services |
| Care consumption (detail) |
Hospitalization Medical/paramedical consultation Medicines consumption |
| Procedures | |
| Data collection method | Questionnaire and blood sample obtained by investigating nurse |
| Participant monitoring |
No |
| Links to administrative sources |
No |
| Promotion and access | |
| Promotion | |
| Link to the document | http://www.ncbi.nlm.nih.gov/pubmed/21472744 |
| Link to the document | http://www.ncbi.nlm.nih.gov/pubmed/22689255 |
| Access | |
| Terms of data access (charter for data provision, format of data, availability delay) | To be defined |
| Access to aggregated data |
Access on specific project only |
| Access to individual data |
Access on specific project only |
