ASCHI - Apathy in Schizophrenia: A Case-Control Clinical and Neuropsychological Study

Head :
Lévy Richard, INSERM MEDU 945, Centre de Recherche-Institut du Cerveau et de la Moelle (CR-ICM), Hôpital de la Pitié Salpétrière

Last update : 07/04/2015 | Version : 1 | ID : 8593

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Métadonnées
Identification
General Aspects
Scientific investigator(s) (Contact)
Collaborations
Funding
Governance of the database
Additional contact
Type of database
Database objective
Population type
Dates
Size of the database
Data
Procedures
Promotion
Access
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General
Identification
Detailed name Apathy in Schizophrenia: A Case-Control Clinical and Neuropsychological Study
Sign or acronym ASCHI
CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation CNIL no. 912451 / CCTIRS no. 12.297
General Aspects
Medical area Neurology
Psychology and psychiatry
Keywords apathy, schizophrenia
Scientific investigator(s) (Contact)
Name of the director Lévy
Surname Richard
Address Hôpital de la Pitié Salpétrière, 75013 Paris
Phone +33 (0)1 49 28 24 32
Email richard.levy@sat.aphp.fr
Unit INSERM MEDU 945, Centre de Recherche-Institut du Cerveau et de la Moelle (CR-ICM), Hôpital de la Pitié Salpétrière
Organization APHP
Collaborations
Funding
Funding status Public
Details INSERM, APHP
Governance of the database
Sponsor(s) or organisation(s) responsible INSERM
Organisation status Public
Additional contact
Main features
Type of database
Type of database Study databases
Study databases (details) Case control study
Database recruitment is carried out by an intermediary A selection of health institutions and services
Database recruitment is carried out as part of an interventional study No
Database objective
Main objective The main objective is to confirm that schizophrenic patients are apathetic compared to health volunteers.
Secondary objectives:
- to investigate if apathy is related to a particular aspect of the disease (i.e., negative or positive symptomatology);
- to investigate if apathy correlates with executive dysfunction;
- to investigate if apathy is associated with a specific mechanism using an experimental task specially designed to characterise different mechanisms (i.e., "a-motivation", "cognitive inertia", and "uncoupling");
- to investigate if there is a volumetric abnormality affecting the executive system in apathetic schizophrenic patients;
- to link these possible volumetric abnormalities to the prefrontal cortex-basal ganglia circuits according to a specific apathy subtype within the apathetic schizophrenic group.
Inclusion criteria Healthy volunteers:
-Male or female;
-Aged 20 to 55;
-With health insurance.

Exclusion criteria:
-History of neurological disorder;
-Previous head injury;
-Alcohol or substance abuse;
-On psychotropic medication;
-Contraindication to MRI.

Schizophrenia patients:
-Male or female;
-Aged 20 to 55;
-With health insurance;
-Daignosed as schizophrenic according to DSM-IV R criteria;
-Illness with a duration of over 5 years;
-Clinical stability during the past 2 months (defined as no treatment modification or hospitalisation 2 months prior to evaluation).

Exclusion criteria:
-Schizo-affective disorder;
-History of neurological disorders (past or present);
-Previous head injury;
-Alcohol or substance abuse;
-Contraindication to MRI.
Population type
Age Adulthood (19 to 24 years)
Adulthood (25 to 44 years)
Adulthood (45 to 64 years)
Population covered Sick population
Gender Male
Woman
Geography area Local
French regions covered by the database Île-de-France
Detail of the geography area Psychiatric department in Corentin Celton Hospital
Data collection
Dates
Date of first collection (YYYY or MM/YYYY) 2012
Size of the database
Size of the database (number of individuals) < 500 individuals
Details of the number of individuals 12 schizophrenic patients; 15 healthy volunteers.
Data
Database activity Current data collection
Type of data collected Clinical data
Paraclinical data
Clinical data (detail) Medical registration
Details of collected clinical data Apathy (measured by Starkstein's Apathy Evaluation Scale), neuropsychological performance: global mental efficience (Mill Hill B, PM 38), frontal assessments (BREF, MCST, TMT A and B, Stroop, verbal fluences), social cognition (SEA); memory (Grober and Buschke, direct-indirect digit span), instrumental functions: Rey figure), positive and negative symptomatology: PANSS, SANS/SAPS, Calgary Scale, SDS.
Paraclinical data (detail) Volumetric brain abnormalities.
Presence of a biobank No
Health parameters studied Health event/morbidity
Procedures
Participant monitoring No
Links to administrative sources No
Promotion and access
Promotion
Access
Terms of data access (charter for data provision, format of data, availability delay) Contact the scientist in charge.
Access to aggregated data Access on specific project only
Access to individual data Access on specific project only

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