ALMA+ - Aluminium in water conveyance and Alzheimers disease 
Head :
Rondeau Virginie, Unité Inserm : U897
Last update : 09/05/2017 | Version : 2 | ID : 3594
| General | |
| Identification | |
| Detailed name | Aluminium in water conveyance and Alzheimers disease |
| Sign or acronym | ALMA+ |
| CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation | CNIL: 998055 (18/05/1998) |
| General Aspects | |
| Medical area |
Neurology Psychology and psychiatry |
| Health determinants |
Genetic Social and psychosocial factors |
| Keywords | water, silica, Aluminium, risk factors |
| Scientific investigator(s) (Contact) | |
| Name of the director | Rondeau |
| Surname | Virginie |
| Address | 146 rue Léo Saignat 33076 Bordeaux cedex |
| Phone | +33 (0)5 57 57 45 31 |
| virginie.rondeau@isped.u-bordeaux2.fr | |
| Unit | Unité Inserm : U897 |
| Organization | INSERM - Institut National de la Santé et de la Recherche |
| Collaborations | |
| Funding | |
| Funding status |
Mixed |
| Details | AFSSE (Agence Francaise de Sécurité Sanitaire Environnementale), Danone |
| Governance of the database | |
| Sponsor(s) or organisation(s) responsible | ISPED- Institut de santé publique d'épidémiologie et de développement |
| Organisation status |
Public |
| Additional contact | |
| Main features | |
| Type of database | |
| Type of database |
Study databases |
| Study databases (details) |
Cohort study |
| Database recruitment is carried out by an intermediary |
A population file |
| Database recruitment is carried out as part of an interventional study |
No |
| Additional information regarding sample selection. | Subjects randomly chosen from the electoral lists of the selected municipalities. The subjects have then been contacted to participate to the study. |
| Database objective | |
| Main objective | Study the relation between minerals in drinking water and especially aluminium, and the development of Alzheimers disease in 75 or more years old subjects. Verify if high concentrations of aluminium (more than 50mg/l of water) can improve the risk of dementia. |
| Inclusion criteria | 75 or more years old subjects, exposed to high concentrations of aluminium in drinking water (Al>50mcg/l), residents in 14 towns of Dordogne, different than the ones included in the PAQUID cohort. 75 or more years old subjects participating to the PAQUID cohort, residents in one of the non-exposed towns (Al<50mcg/l) in Dordogne. Exclusion criteria: subjects recently arrived in town. Inclusion period: May 1999 - January 2001. |
| Population type | |
| Age |
Elderly (65 to 79 years) Great age (80 years and more) |
| Population covered |
General population |
| Gender |
Male Woman |
| Geography area |
Departmental |
| French regions covered by the database |
Aquitaine Limousin Poitou-Charentes |
| Detail of the geography area | 14 municipalities in Dordogne |
| Data collection | |
| Dates | |
| Date of first collection (YYYY or MM/YYYY) | 05/1999 |
| Date of last collection (YYYY or MM/YYYY) | 12/2004 |
| Size of the database | |
| Size of the database (number of individuals) |
< 500 individuals |
| Details of the number of individuals | 400 |
| Data | |
| Database activity |
Data collection completed |
| Type of data collected |
Clinical data Declarative data Biological data |
| Clinical data (detail) |
Medical registration |
| Details of collected clinical data | Clinical examination at inclusion and during the follow-up. Information collected during the clinical examination: clinical check, complementary biological and radiological check up. |
| Declarative data (detail) |
Face to face interview |
| Details of collected declarative data | Clinical examination at inclusion and during the follow-up. Information collected during the clinical examination: clinical check, complementary biological and radiological check up. |
| Biological data (detail) | Samples collected: cholesterol, triglycerides, glycemia, apolipoproteines, creatinine, circulating proteines involved in metal transportation |
| Presence of a biobank |
Yes |
| Contents of biobank |
Serum DNA |
| Details of biobank content | Serum bank, DNA bank |
| Health parameters studied |
Health event/morbidity Health event/mortality |
| Procedures | |
| Quality procedure(s) used | Coherence request after computer data entry. Missing data asked back to the original file and/or to the patient. |
| Participant monitoring |
Yes |
| Details on monitoring of participants | 3-4 years |
| Links to administrative sources |
Yes |
| Linked administrative sources (detail) | DDASS (Department Direction of Health and Social Affaires),, CepiDC (Epidemiologic center on medical causes of death), Gironde general council |
| Promotion and access | |
| Promotion | |
| Link to the document | http://tinyurl.com/HAL-ALMA |
| Description | Liste des publications dans HAL |
| Link to the document | http://tinyurl.com/Pubmed-ALMA |
| Description | Liste des publications dans Pubmed |
| Access | |
| Terms of data access (charter for data provision, format of data, availability delay) | Data utilization possible for academic teams and for industrials. |
| Access to aggregated data |
Access on specific project only |
| Access to individual data |
Access on specific project only |
