GAZEL - 20,000 Volunteers for Medical Research
Head :
Goldberg Marcel, UMS 011 : Cohortes épidémiologiques en population
Zins Marie, UMS 011 : Cohortes épidémiologiques en population
Zins Marie, UMS 011 : Cohortes épidémiologiques en population
Last update : 10/25/2019 | Version : 5 | ID : 3476
| General | |
| Identification | |
| Detailed name | 20,000 Volunteers for Medical Research |
| Sign or acronym | GAZEL |
| CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation | CNIL # 105 728 |
| General Aspects | |
| Medical area |
Biology Cancer research Cardiology Disability/handicap Endocrinology and metabolism Gastroenterology et hepatology Hematology Neurology Occupational Medicine Pneumology Psychology and psychiatry Rheumatology Traumatology Urology, andrology and nephrology |
| Study in connection with Covid-19 |
No |
| Health determinants |
Genetic Geography Healthcare system and access to health care services Lifestyle and behavior Medicine Nutrition Occupation Pollution Social and psychosocial factors |
| Keywords | Genarl-purpose cohort, adults, occupational health, social determinants, aging |
| Scientific investigator(s) (Contact) | |
| Name of the director | Goldberg |
| Surname | Marcel |
| Address | 16 avenue Paul Vaillant-Couturier |
| Phone | (33)1 77747428 |
| marcel.goldberg@inserm.fr | |
| Unit | UMS 011 : Cohortes épidémiologiques en population |
| Organization | INSERM & UVSQ |
| Name of the director | Zins |
| Surname | Marie |
| Address | 16 avenue Paul Vaillant-Couturier |
| Phone | (33) 1 77747428 |
| marie.zins@inserm.fr | |
| Unit | UMS 011 : Cohortes épidémiologiques en population |
| Organization | INSERM & UVSQ |
| Collaborations | |
| Participation in projects, networks and consortia |
Yes |
| Details | Consortiums and collaborations :- Sickness Absence Research Collaboration (SARC) : http://ucl-sarc.org/index.html - IDEAR (Integrated Datasets across Europe for Ageing Research)- BBMRI-LPC- P3G |
| Funding | |
| Funding status |
Public |
| Details | CCAS, IReSP, various grants |
| Governance of the database | |
| Sponsor(s) or organisation(s) responsible | INSERM |
| Organisation status |
Public |
| Additional contact | |
| Main features | |
| Type of database | |
| Type of database |
Study databases |
| Study databases (details) |
Cohort study |
| Database recruitment is carried out by an intermediary |
A population file An administrative base or a register |
| Database recruitment is carried out as part of an interventional study |
No |
| Additional information regarding sample selection. | All eligible subjects were asked by mail to participate . |
| Database objective | |
| Main objective | GAZEL was set up in 1989 among workers of Électricité de France-Gaz de France (EDF-GDF). It was designed as an “open epidemiologic laboratory” characterized by a broad coverage of health problems and determinants and accessible to the community of researchers. At study inception in 1989, the GAZEL Cohort Study included 20,625 volunteers (15,011 men and 5,614 women) then aged from 35 to 50 years. The data routinely collected cover diverse dimensions and come from different sources: annual self-administered questionnaire (morbidity, lifestyles, life events, etc.); personnel department of EDF-GDF for social, demographic, and occupational characteristics; EDF-GDF special social insurance fund (for sickness absences and cancer and ischemic heart disease registries), occupational medicine (occupational exposure and working conditions), Social Action Fund (healthcare utilization), Health Screening Centres for standardized health examination and the National Death Register (causes of death); a biobank including more than 8,000 blood samples was also set up. Today, more than 40 ancillary projects on diversified themes have been set up in the GAZEL Cohort Study by some 30 French and foreign teams from Denmark, Germany, Belgium, Canada, Great Britain, Sweden, Finland, and USA. Health problems as diverse as migraine, postmenopausal osteoporosis, ischemic heart disease, depression, musculoskeletal diseases, or traffic accidents have been the object of research projects in this cohort. They take into account risk factors that are behavioural, social, psychological, occupational, and medical. A substantial proportion of the research work has focused on the problem of social inequalities in health and their occupational, personal, and social determinants using a life course perspective. |
| Inclusion criteria | EDF-GDF workers aged 35-50 at inception. |
| Population type | |
| Age |
Adulthood (45 to 64 years) Elderly (65 to 79 years) |
| Population covered |
General population |
| Pathology | |
| Gender |
Male Woman |
| Geography area |
National |
| Detail of the geography area | All France |
| Data collection | |
| Dates | |
| Date of first collection (YYYY or MM/YYYY) | 1989 |
| Date of last collection (YYYY or MM/YYYY) | 2019 |
| Size of the database | |
| Size of the database (number of individuals) |
Greater than 20 000 individuals |
| Details of the number of individuals | 20 625 |
| Data | |
| Database activity |
Current data collection |
| Type of data collected |
Declarative data Paraclinical data Biological data Administrative data |
| Declarative data (detail) |
Paper self-questionnaire |
| Paraclinical data (detail) | Weight, height, waist-hip ratio, body fat mass, visual acuity, hearing, spirometry, electrocardiogram, blood pressure, assessment of cognitive function (Mini Mental State Examination (MMSE), Digit Symbol Substitution Test (DSST), Free and Cued Selective Reminding Test with Immediate Recall (FCSRT-IR), Trail Making Test (TMT A& B), semantic fluency ), assessment of physical function (Standing Balance Test, Walking Speed, Handgrip Strength Test, Finger-Tapping Test (FTT)) |
| Biological data (detail) | Blood count, glucose, total cholesterol, HDL cholesterol, ALT, creatinine, triglycerides, micro albumin, Gamma GT |
| Administrative data (detail) | Job history, health care consumption, hospital stays.mortality data. |
| Presence of a biobank |
Yes |
| Contents of biobank |
Whole blood Plasma Buccal cells DNA |
| Details of biobank content | Serum, lithium heparin plasma, EDTA K3 plasma, natrium citrate plasma, buffy coat. |
| Health parameters studied |
Health event/morbidity Health event/mortality Health care consumption and services Quality of life/health perception |
| Care consumption (detail) |
Hospitalization Medical/paramedical consultation Medicines consumption |
| Procedures | |
| Data collection method | Yearly self-questionnaire. Follow-up also through national health and socioeconomic administrative databases. |
| Participant monitoring |
Yes |
| Monitoring procedures |
Monitoring by contact with the participant (mail, e-mail, telephone etc.) Monitoring by crossing with a medical-administrative database |
| Details on monitoring of participants | Yearly self-questionnaire. Linkage to the French national health and socioeconomic administrative databases. Periodic health examination. |
| Links to administrative sources |
Yes |
| Linked administrative sources (detail) | EDF-GDF files, health care consumption, hospital database, causes of death database. |
| Promotion and access | |
| Promotion | |
| Link to the document | Goldberg et al, Int J Epid 2015.pdf |
| Description | List of publications in HAL |
| Link to the document | http://www.ncbi.nlm.nih.gov/pubmed/?term=(gazel) NOT Gazel[Author] |
| Description | List of publications in Pubmed |
| Link to the document | http://www.hal.inserm.fr/GAZEL |
| Link to the document | http://www.ncbi.nlm.nih.gov/pubmed/?term=Gazel+NOT+Grotte[Title%2FAbstract]+NOT+Gazel[Author]+NOT+TEMPO+NOT+12766468[uid]+NOT+11151601[uid] |
| Access | |
| Presence of document that lists variables and coding procedures |
Yes |
| Terms of data access (charter for data provision, format of data, availability delay) |
Permanent call for research projects
Data catalogue available on dedicated website |
| Access to aggregated data |
Free access |
| Access to individual data |
Access on specific project only |
