CORINES - Identification of adrenal insufficiency and / or Cushing's syndrome in patients treated with inhaled corticosteroids 
Responsable(s) :
Molimard Mathieu, Service de Pharmacologie, CIC-P 0005-INSERM U657- Université Bordeaux Segalen
Moore Nicholas, Service de Pharmacologie, CIC-P 0005-INSERM U657- Université Bordeaux Segalen
Moore Nicholas, Service de Pharmacologie, CIC-P 0005-INSERM U657- Université Bordeaux Segalen
Date de modification : 05/09/2017 | Version : 1 | ID : 2932
| Général | |
| Identification | |
| Nom détaillé | Identification of adrenal insufficiency and / or Cushing's syndrome in patients treated with inhaled corticosteroids |
| Sigle ou acronyme | CORINES |
| Numéro d'enregistrement (ID-RCB ou EUDRACT, CNIL, CPP, etc.) | CNIL |
| Thématiques générales | |
| Domaine médical |
Endocrinology and metabolism Pediatrics Pneumology |
| Déterminants de santé |
Iatrogenic Medicine |
| Mots-clés | Adrenal insufficiency, Cushing's syndrome, inhaled corticosteroids, retrospective cohort, pharmacoepidemiology, Department of Pharmacology, Bordeaux |
| Responsable(s) scientifique(s) | |
| Nom du responsable | Molimard |
| Prénom | Mathieu |
| Adresse | Bât du Tondu - Case 41 - 146, Rue L2o Saignat - 33076 BORDEAUX Cedex |
| Téléphone | + 33 (0)5 57 57 46 75 |
| mathieu.molimard@pharmaco.u-boreaux2.fr | |
| Laboratoire | Service de Pharmacologie, CIC-P 0005-INSERM U657- Université Bordeaux Segalen |
| Organisme | Université Bordeaux |
| Nom du responsable | Moore |
| Prénom | Nicholas |
| Adresse | Bât du Tondu - Case 41 - 146, Rue L2o Saignat - 33076 BORDEAUX Cedex |
| Téléphone | + 33 (0)5 57 57 46 75 |
| nicholas.moore@pharmaco.u-boreaux2.fr | |
| Laboratoire | Service de Pharmacologie, CIC-P 0005-INSERM U657- Université Bordeaux Segalen |
| Organisme | Université Bordeaux |
| Collaborations | |
| Financements | |
| Financements |
Mixed |
| Précisions | Laboratoires Merck and Co. (soutien inconditionnel) - Merck and Co. (unconditional support) |
| Gouvernance de la base de données | |
| Organisation(s) responsable(s) ou promoteur | Service de Pharmacologie, CIC-P 0005-INSERM U657- Université Bordeaux Segalen |
| Statut de l’organisation |
Secteur Public |
| Contact(s) supplémentaire(s) | |
| Caractéristiques | |
| Type de base de données | |
| Type de base de données |
Morbidity registers |
| Informations complémentaires concernant la constitution de l'échantillon | Patients were selected by pulmonologists, pediatricians, endocrinologists and emergency physicians in metropolitan France who agreed to participate. They were to identify all patients with adrenal insufficiency and / or Cushing's syndrome under inhaled corticosteroid therapy during the years 2000 to 2005 |
| Objectif de la base de données | |
| Objectif principal | The objectives were to identify cases of adrenal insufficiency and / or Cushing's syndrome in patients taking inhaled corticosteroids during the years 2000 to 2005 and describe the circumstances of occurrence of these events in order to propose recommendations to prevent them. |
| Critères d'inclusion | Children or adults treated with inhaled corticosteroids; Having presented symptoms suggestive of adrenal insufficiency and / or Cushing's syndrome during the years 2000 to 2005; First symptoms having appeared during treatment or within 3 months after discontinuation; Patients without adrenal insufficiency and / or Cushing's syndrome known before initiation of treatment with inhaled corticosteroids. |
| Type de population | |
| Age |
Infant (28 days to 2 years) Early childhood (2 to 5 years) Childhood (6 to 13 years) Adolescence (13 to 18 years) Adulthood (19 to 24 years) Adulthood (25 to 44 years) Adulthood (45 to 64 years) Elderly (65 to 79 years) Great age (80 years and more) |
| Population concernée |
Sick population |
| Sexe |
Male Woman |
| Champ géographique |
National |
| Détail du champ géographique | Pulmonologists, pediatricians, endocrinologists, emergency physicians in metropolitan France |
| Collecte | |
| Dates | |
| Année du premier recueil | 2005 |
| Année du dernier recueil | 2006 |
| Taille de la base de données | |
| Taille de la base de données (en nombre d'individus) |
< 500 individuals |
| Détail du nombre d'individus | 70 patients éligibles dont 32 patients inclus 70 eligible patients, of whom 32 patients included |
| Données | |
| Activité de la base |
Data collection completed |
| Type de données recueillies |
Clinical data |
| Données cliniques, précisions |
Direct physical measures |
| Existence d’une biothèque |
No |
| Paramètres de santé étudiés |
Health event/morbidity Health event/mortality Health care consumption and services |
| Consommation de soins, précisions |
Hospitalization Medicines consumption |
| Modalités | |
| Mode de recueil des données | Using a questionnaire the physicians reported all patients meeting the inclusion criteria. For each case, a second questionnaire was sent to the physician to collect all treatments taken by the patient including treatment by systemic corticosteroids, as well as clinical and laboratory findings that could clarify the diagnosis and circumstances of event occurrence. |
| Suivi des participants |
No |
| Appariement avec des sources administratives |
No |
| Valorisation et accès | |
| Valorisation et accès | |
| Lien vers le document | http://www.ncbi.nlm.nih.gov/pubmed/18707191 |
| Accès | |
| Charte d'accès aux données (convention de mise à disposition, format de données et délais de mise à disposition) | A confidential study report was submitted to the pharmaceutical company. The study report and scientific communications (posters, paper, ...) are validated by the study Scientific Committee. Ownership of study data is the subject of an agreement between the University of Bordeaux Segalen and the pharmaceutical company. Terms for third-party access to the database are to be defined. |
| Accès aux données agrégées |
Access on specific project only |
| Accès aux données individuelles |
Access on specific project only |
