ITMO Santé Publique
ITMO Santé Publique
Date de modification : 07/05/2021 | Version : 4 | ID : 3406
| Général | |
| Identification | |
| Nom détaillé | French longitudinal study from childhood |
| Sigle ou acronyme | ELFE |
| Numéro d'enregistrement (ID-RCB ou EUDRACT, CNIL, CPP, etc.) | CNIL n°910504 - CNIS n°2011X716AU - CPP n°IDF IX-11-024 (13/05/2011) |
| Thématiques générales | |
| Domaine médical |
Biology Dermatology, venereology Disability/handicap Endocrinology and metabolism Gynecology/ obstetrics Infectious diseases Ophthalmology Otolaryngology or ENT Pediatrics Pneumology Psychology and psychiatry Study of allergies Traumatology |
| Etude en lien avec la Covid-19 |
Yes |
| Déterminants de santé |
Geography Healthcare system and access to health care services Lifestyle and behavior Nutrition Occupation Pollution Social and psychosocial factors |
| Mots-clés | family, pregnancy, growth, development, pollution, environment, nutrition, living environment, schooling, socialisation, children |
| Responsable(s) scientifique(s) | |
| Nom du responsable | Charles |
| Prénom | Marie-Aline |
| Adresse | 9, cours des Humanités<br>93322 Aubervilliers Cedex |
| Téléphone | +33 (0)1 56 06 43 22 |
| marie-aline.charles@inserm.fr | |
| Laboratoire | Elfe INED-Inserm joint unit |
| Organisme | Inserm |
| Nom du responsable | Geay |
| Prénom | Bertrand |
| Adresse |
9, cours des Humanités 93322 Aubervilliers Cedex |
| bertrand.geay@u-picardie.fr | |
| Laboratoire | “Elfe” INED-INSERM joint unit |
| Organisme | University of Picardie |
| Collaborations | |
| Participation à des projets, des réseaux, des consortiums |
Yes |
| Précisions | European Lifecycle project |
| Financements | |
| Financements |
Public |
| Précisions | Ministry for Higher Education and Research, the Ministry for Labour, Employment and Health, and the Ministry for Ecology Sustainable Development, Transport and Housing, + RE-CO-NAI is the recipient of an ANR "Investing in the Future" grant |
| Gouvernance de la base de données | |
| Organisation(s) responsable(s) ou promoteur | French National Institute for Demographic Studies (INED) |
| Statut de l’organisation |
Secteur Public |
| Organisation(s) responsable(s) ou promoteur | French National Institute for Health and Medical Research (INSERM) |
| Statut de l’organisation |
Secteur Public |
| Existence de comités scientifique ou de pilotage |
Yes |
| Contact(s) supplémentaire(s) | |
| Caractéristiques | |
| Type de base de données | |
| Type de base de données |
Study databases |
| Base de données issues d'enquêtes, précisions |
Cohort study |
| Origine du recrutement des participants |
A selection of health institutions and services |
| Le recrutement dans la base de données s'effectue dans le cadre d'une étude interventionnelle |
No |
| Informations complémentaires concernant la constitution de l'échantillon | random sample of maternity units |
| Objectif de la base de données | |
| Objectif principal |
- Track changes in the child's living conditions (family, social environment, etc.) and measure their impact on his or her physical and mental
development. - Study the interactions between these living conditions and the child's school career - Measure the impact of events during pregnancy and the child's health at birth on the latter's subsequent development - Observe eating habits and their effects on growth (overweight, obesity) - Assess the child's exposure to chemical, physical or environmental pollutants - Measure the incidence and prevalence of childhood pathologies at different stages in growth - Study associations between pathologies and exposure to environmental pollutants Elfe is one of the two cohorts making up the RECO-NAI research platform, the other being Epipage 2. The general aim of this platform is to set up an infrastructure to support the collection, highly secure storage and distribution of data on pregnancy, birth and children. The platform will use the information yielded by the child cohorts, both followed from birth, to address key issues in the areas of children's health, development and socialization from an overarching, multidisciplinary perspective. It will also ensure that the cohorts are given a high profile in the world of academic research (French and international), as well as among bodies, organizations and manufacturers with an interest in children. This will ensure optimum use of the data collected and promote their dissemination. |
| Critères d'inclusion |
- Children born after 33 weeks of pregnancy
- single or twin pregnancy - in mainland France - mother aged 18 years and over |
| Type de population | |
| Age |
Newborns (birth to 28 days) Infant (28 days to 2 years) Early childhood (2 to 5 years) Childhood (6 to 13 years) Adolescence (13 to 18 years) |
| Population concernée |
General population |
| Pathologie | |
| Sexe |
Male Woman |
| Champ géographique |
National |
| Détail du champ géographique | Mainland France |
| Collecte | |
| Dates | |
| Année du premier recueil | 2011 |
| Taille de la base de données | |
| Taille de la base de données (en nombre d'individus) |
[10 000-20 000[ individuals |
| Détail du nombre d'individus | 18300 |
| Données | |
| Activité de la base |
Current data collection |
| Type de données recueillies |
Clinical data Declarative data Paraclinical data Biological data Administrative data |
| Données cliniques, précisions |
Direct physical measures Medical registration |
| Détail des données cliniques recueillies | > Data available in the medical records at the time of birth: neonatal characteristics (weight, height, gestational age, congenital anomalies, circumstances of birth, infections, etc.) > Medical examinations: vaccination, hearing, eyesight, weight/height, asthma, allergies, genital organs and neuropsychomotor tests at different ages |
| Données déclaratives, précisions |
Paper self-questionnaire Internet self-questionnaire Face to face interview Phone interview |
| Détail des données déclaratives recueillies | Exposure: medication, pollution, occupational, tobacco use, alcohol, diet, chemical and physical agents, social status. > Results: congenital anomalies, infections, growth/obesity, neurological development, asthma/allergies, pubescent development, sleep, mental health > Use of healthcare resources |
| Données paracliniques, précisions | pregnancy monitoring tests, medical imaging |
| Données biologiques, précisions | At birth, urine, venous blood and maternal hair post-partum: Breast milk, meconium, stools (at D3); urine, hair, infant stools at 3.5 years |
| Données administratives, précisions | pairing with SNIIR-AM data |
| Existence d’une biothèque |
Yes |
| Contenu de la biothèque |
Whole blood Serum Plasma Cord blood Fluids (saliva, urine, amniotic fluid, …) Tissues DNA DNAc/RNAm Others |
| Détail des éléments conservés | plasma, serum, whole blood, red blood cells, buffy coat, urine, hair, milk, stools and meconium, RNA (sub-sample) |
| Paramètres de santé étudiés |
Health event/morbidity Health care consumption and services Quality of life/health perception |
| Consommation de soins, précisions |
Hospitalization Medical/paramedical consultation Medicines consumption |
| Modalités | |
| Mode de recueil des données | - Self-administered questionnaire on diet and exposure during pregnancy completed by the mother in the maternity unit.- notes from obstetrics record- Face-to-face meeting, at home- Telephone surveys- Self-administered questionnaires on infant diet between |
| Nomenclatures employées | ICD-10 |
| Suivi des participants |
Yes |
| Modalités de suivi des participants |
Monitoring by contact with the participant (mail, e-mail, telephone etc.) Monitoring by crossing with a medical-administrative database |
| Détail du suivi | annual follow-up for up to 3 years, then every 2-3 years |
| Appariement avec des sources administratives |
Yes |
| Sources administratives appariées, précisions | SNIIR-AM database |
| Valorisation et accès | |
| Valorisation et accès | |
| Lien vers le document | http://tinyurl.com/HAL-ELFE |
| Description | List of publications in HAL |
| Lien vers le document | http://tinyurl.com/Pubmed-ELFE |
| Description | List of publications in Pubmed |
| Lien vers le document | Elfe.pdf |
| Accès | |
| Site internet dédié | https://www.elfe-france.fr/ |
| Existence d’un document qui répertorie les variables et les modalités de codage |
Yes |
| Charte d'accès aux données (convention de mise à disposition, format de données et délais de mise à disposition) |
Data access platform: access via the website: www.elfe-france.fr/acces-donnees or direct access: https://pandora.vjf.inserm.fr/public/
The proposals should be submitted to an ELFE data access committee which will determine the relevance of the project and the suitability of the data requested. |
| Accès aux données agrégées |
Access on specific project only |
| Accès aux données individuelles |
Access on specific project only |
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