Etude longitudinale sur des patients obèses diabétiques devant bénéficier d'une chirurgie bariatrique ABOS : Atlas Biologique de l'Obésité Sévère ABOS : Atlas Biologique de l'Obésité Sévère Influence of the Glycemic and Ponderal Status on Tissues Gene Expression (Biological Tissue Collection) PEF5682 Portail Épidémiologie-France Portail Épidémiologie-France | Health Databases Portail Épidémiologie-France 2026 04/04/2026 https://epidemiologie-france.aviesan.fr/ Portail Épidémiologie-France Portail Epidemiologie-France François Pattou 26/03/2013 26/03/2013 07/11/2014 2 2 François Pattou ABOS : Atlas Biologique de l'Obésité Sévère - Etude longitudinale sur des patients obèses diabétiques devant bénéficier d'une chirurgie bariatrique ABOS (Atlas Biologique de l'Obésité Sévère) - Influence of the Glycemic and Ponderal Status on Tissues Gene Expression (Biological Tissue Collection) Etude longitudinale sur des patients obèses diabétiques devant bénéficier d'une chirurgie bariatrique ABOS : Atlas Biologique de l'Obésité Sévère ABOS : Atlas Biologique de l'Obésité Sévère Influence of the Glycemic and Ponderal Status on Tissues Gene Expression (Biological Tissue Collection) François Pattou Programme IT-DiabProgramme IMI-DIRECT CHRU Lille INSERM U859 - CHRU - 1 Place Verdun CHRU LilleVaiomerIMI - Innovative Medicines Initiative / DIRECT - Diabetes Research on Patient Stratification CHRU LilleVaiomerIMI - Innovative Medicines Initiative / DIRECT - Diabetes Research on Patient Stratification CHRU François Pattou François Pattou 26/03/2013 26/03/2013 07/11/2014 17/11/2014 2 2 François Pattou CNIL CPP 06/49, DGS 2006/0307 CPP 06/49, DGS 2006/0307 chirurgie bariatrique score clinico-biologique prédictif rémission diabetis bariatric surgery obesity Endocrinologie et métabolisme Endocrinology and metabolism Mode de vie et comportements Nutrition Génétique Nutrition Genetic Objectif de la base de données : Déterminer un score clinico-biologique prédictif de la rémission du diabète. La rémission du diabète de type 2 (DT2) sera définie 12 mois après l’intervention, par l’absence de diabète selon les critères de l’American Diabetes Association (ADA, HbA1c inférieure à 6.5 %, ET glycémie à jeun inférieure à 7 mmol/L ET glycémie à 2h après hyperglycémie provoqué par voie orale inférieure à 11.1 mmol/L, en l’absence de tout traitement hypoglycémiant) Database objective : The objective of this trial is to study the influence of phenotypic characteristics on gene expression of tissues involved in glucose or/and lipidic metabolism with the creation of a collection of biological samples for research on obesity and diabetes. 06/2006 Collecte des données active Current data collection France France France National individuel individuals 320 patients obèses (IMC supérieur à 35) et présentant un diabète de type 2 selon les critères de l’American Diabetes Association et devant bénéficier d'une chirurgie bariatrique et d'un suivi post-opératoire pendant au moins 1 an • Age between 18 and 65 years. • Indication of abdominal surgery requiring laparotomy or coelioscopy for obesity surgery, a cholecystectomy, or a parietal surgery. • phenotype corresponding to one of the following four cases 1. BMI greater than or equal to 35 kg/m2 and diabetes defined by glucose greater or equal to 7 mmol/l fasting and/or greater than or equal to 11.1 mmol/l, 120 min after glucose intake (OGTT). 2. BMI greater than or equal to 35 kg/m2 and IGT defined by a higher than 6 mmol/l and less than 7 mmol/l fasting blood glucose, and/or greater than 7.8 mmol/l and less than 11.1 mmol/l, 120 min after glucose intake (OGTT). 3. BMI greater than or equal to 35 kg/m2 and with normal glucose tolerance defined by a blood glucose of less than or equal to 6 mmol/l and/or less than or equal to 7.8 mmol/l, 120 min after glucose intake (OGTT). 4. BMI inferior to 27 kg/m2 and with normal glucose tolerance defined by a blood glucose of less than or equal to 6 mmol/l and/or less than or equal to 7.8 mmol/l, 120 min after glucose intake (OGTT) (control group). 5. BMI between 27 and 35 27 kg/m2 and with normal glucose tolerance defined by a blood glucose less than or equal to 6 mmol/l and/or less than or equal to 7.8 mmol/l, 120 min after glucose intake (OGTT) (control group). Nombre d'individus : 850 Number of individuals: 850 Recrutement via une sélection de services ou établissements de santé Recruiting through a selection of health institutions and services Intervention au niveau individuel Performed at individual level Enfance (6 à 13 ans) Adolescence (13 à 18 ans) Adulte (19 à 24 ans) Adulte (25 à 44 ans) Adulte (45 à 64 ans) Childhood (6 to 13 years) Adolescence (13 to 18 years) Adulthood (19 to 24 years) Adulthood (25 to 44 years) Adulthood (45 to 64 years) Population générale General population Masculin Féminin Male Female Bases de données issues d’enquêtes Study databases Etudes longitudinales (hors cohortes) Longitudinal study (except cohorts) Données cliniques : Données déclaratives : Auto-questionnaire papierFace à faceTéléphone Données biologiques : ----- Clinical data: Prospective assessment of clinical features before and after bariatric surgery: weight, BMI, blood pressure Declarative data: Paper self-questionnaireFace to face interviewPhone interview Biological data: Prospective assessment of biological features before and after bariatric surgery: alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), prothrombin time, platelets, serum triglyceride, cholesterolemia, fasting blood glucose, fasting insulin, blood glucose and insulin 120 minutes after ingestion of glucose (oral glucose tolerance test) Sang total Sérum Plasma Cellules sanguines isolées Tissus ADN Whole blood Serum Plasma Blood cells isolated Tissues DNA 6 tubes de sang (EDTA 40ml, tube sec 10ml et tube hépariné 10ml) Liver samples before and at 1 and 5 years after bariatric surgeryMuscle samples before and at 1 year after bariatric surgerySubcutaneous fat samples before and at 3 month and 1 year after bariatric surgeryVisceral fat samples in the great omentum before bariatric surgeryIntestinal samples during gastric by-pass surgeryBlood samples baseline and at at 1, 3 months, 1, 2, 5 years after surgery Evénements de santé/morbidité Evénements de santé/mortalité Health event/morbidity Health event/mortality Quality methods used: monitoring promoteur Time Series François Pattou au moins 1 an Prospective assessment of clinical and biological features before and after bariatric surgeryLiver samples before and at 1 and 5 years after bariatric surgeryMuscle samples before and at 1 year after bariatric surgerySubcutaneous fat samples before and at 3 month and 1 year after bariatric surgeryVisceral fat samples in the great omentum before bariatric surgeryIntestinal samples during gastric by-pass surgeryBlood samples baseline and at at 1, 3 months, 1, 2, 5 years after surgery Liver samples before and at 1 and 5 years after bariatric surgeryMuscle samples before and at 1 year after bariatric surgerySubcutaneous fat samples before and at 3 month and 1 year after bariatric surgeryVisceral fat samples in the great omentum before bariatric surgeryIntestinal samples during gastric by-pass surgeryBlood samples baseline and at at 1, 3 months, 1, 2, 5 years after surgery before and after bariatric surgery Dossier cliniqueExamen médical : Direct physical measuresMedical registration: Prospective assessment of clinical features before and after bariatric surgery: weight, BMI, blood pressure Auto-questionnaire papierFace à faceTéléphone : Paper self-questionnaireFace to face interviewPhone interview: ----- Prospective assessment of biological features before and after bariatric surgery: alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), prothrombin time, platelets, serum triglyceride, cholesterolemia, fasting blood glucose, fasting insulin, blood glucose and insulin 120 minutes after ingestion of glucose (oral glucose tolerance test) Contacter le responsable scientifique Contact the investigator Contacter le responsable scientifique Contact the investigator Contacter le responsable scientifique Contact the investigator http://tinyurl.com/Hal-ABOS http://tinyurl.com/Pubmed-ABOS http://tinyurl.com/Hal-ABOS http://tinyurl.com/Pubmed-ABOS