56822226/03/201326/03/2013ValidatedValidated07/11/201417/11/2014François Pattouhttp://epidemiologie-france.aviesan.fr/layout/set/print/content/view/full/83631http://epidemiologie-france.aviesan.fr/layout/set/print/content/view/full/83632http://epidemiologie-france.aviesan.fr/layout/set/print/ccontent/xml/(NodeId)/83631Etude longitudinale sur des patients obèses diabétiques devant bénéficier d'une chirurgie bariatriqueInfluence of the Glycemic and Ponderal Status on Tissues Gene Expression (Biological Tissue Collection)ABOS : Atlas Biologique de l'Obésité SévèreABOS (Atlas Biologique de l'Obésité Sévère)CPP 06/49, DGS 2006/0307CPP 06/49, DGS 2006/0307Endocrinologie et métabolismeEndocrinology and metabolismMode de vie et comportementsNutritionGénétiqueNutritionGeneticchirurgie bariatriquescore clinico-biologiqueprédictifrémissiondiabetisbariatric surgeryobesityPattouFrançois1 Place Verdun+ 33 (0)3 20 44 42 73fpattou@univ-lille2.frINSERM U859CHRUPattouFrançois1 Place Verdun+ 33 (0)3 20 44 42 73fpattou@univ-lille2.frINSERM U859CHRUYesProgramme IT-DiabProgramme IMI-DIRECTMixteMixedCHRU LilleVaiomerIMI - Innovative Medicines Initiative / DIRECT - Diabetes Research on Patient StratificationCHRU LilleVaiomerIMI - Innovative Medicines Initiative / DIRECT - Diabetes Research on Patient StratificationCHRU LilleSecteur PublicCHRU LilleSecteur PublicBases de données issues d’enquêtesStudy databasesEtudes longitudinales (hors cohortes)Longitudinal study (except cohorts)Via une sélection de services ou établissements de santéA selection of health institutions and servicesOuiYesIntervention au niveau individuelPerformed at individual levelLiver samples before and at 1 and 5 years after bariatric surgeryMuscle samples before and at 1 year after bariatric surgerySubcutaneous fat samples before and at 3 month and 1 year after bariatric surgeryVisceral fat samples in the great omentum before bariatric surgeryIntestinal samples during gastric by-pass surgeryBlood samples baseline and at at 1, 3 months, 1, 2, 5 years after surgeryDéterminer un score clinico-biologique prédictif de la rémission du diabète. La rémission du diabète de type 2 (DT2) sera définie 12 mois après l’intervention, par l’absence de diabète selon les critères de l’American Diabetes Association (ADA, HbA1c inférieure à 6.5 %, ET glycémie à jeun inférieure à 7 mmol/L ET glycémie à 2h après hyperglycémie provoqué par voie orale inférieure à 11.1 mmol/L, en l’absence de tout traitement hypoglycémiant)The objective of this trial is to study the influence of phenotypic characteristics on gene expression of tissues involved in glucose or/and lipidic metabolism with the creation of a collection of biological samples for research on obesity and diabetes.320 patients obèses (IMC supérieur à 35) et présentant un diabète de type 2 selon les critères de l’American Diabetes Association et devant bénéficier d'une chirurgie bariatrique et d'un suivi post-opératoire pendant au moins 1 an• Age between 18 and 65 years. • Indication of abdominal surgery requiring laparotomy or coelioscopy for obesity surgery, a cholecystectomy, or a parietal surgery. • phenotype corresponding to one of the following four cases 1. BMI greater than or equal to 35 kg/m2 and diabetes defined by glucose greater or equal to 7 mmol/l fasting and/or greater than or equal to 11.1 mmol/l, 120 min after glucose intake (OGTT). 2. BMI greater than or equal to 35 kg/m2 and IGT defined by a higher than 6 mmol/l and less than 7 mmol/l fasting blood glucose, and/or greater than 7.8 mmol/l and less than 11.1 mmol/l, 120 min after glucose intake (OGTT). 3. BMI greater than or equal to 35 kg/m2 and with normal glucose tolerance defined by a blood glucose of less than or equal to 6 mmol/l and/or less than or equal to 7.8 mmol/l, 120 min after glucose intake (OGTT). 4. BMI inferior to 27 kg/m2 and with normal glucose tolerance defined by a blood glucose of less than or equal to 6 mmol/l and/or less than or equal to 7.8 mmol/l, 120 min after glucose intake (OGTT) (control group). 5. BMI between 27 and 35 27 kg/m2 and with normal glucose tolerance defined by a blood glucose less than or equal to 6 mmol/l and/or less than or equal to 7.8 mmol/l, 120 min after glucose intake (OGTT) (control group).Enfance (6 à 13 ans)Adolescence (13 à 18 ans)Adulte (19 à 24 ans)Adulte (25 à 44 ans)Adulte (45 à 64 ans)Childhood (6 to 13 years)Adolescence (13 to 18 years)Adulthood (19 to 24 years)Adulthood (25 to 44 years)Adulthood (45 to 64 years)Population généraleGeneral populationMasculinFémininMaleWomanNationalNationalFranceFrance06/200606/2006[500-1000[ individus[500-1000[ individuals850850Collecte des données activeCurrent data collectionDonnées cliniquesDonnées déclarativesDonnées biologiquesClinical dataDeclarative dataBiological dataDossier cliniqueExamen médicalDirect physical measuresMedical registrationProspective assessment of clinical features before and after bariatric surgery: weight, BMI, blood pressureAuto-questionnaire papierFace à faceTéléphonePaper self-questionnaireFace to face interviewPhone interviewProspective assessment of clinical features before and after bariatric surgery: weight, BMI, blood pressure-----Prospective assessment of biological features before and after bariatric surgery: alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), prothrombin time, platelets, serum triglyceride, cholesterolemia, fasting blood glucose, fasting insulin, blood glucose and insulin 120 minutes after ingestion of glucose (oral glucose tolerance test)OuiYesSang totalSérumPlasmaCellules sanguines isoléesTissusADNWhole bloodSerumPlasmaBlood cells isolatedTissuesDNA6 tubes de sang (EDTA 40ml, tube sec 10ml et tube hépariné 10ml)Liver samples before and at 1 and 5 years after bariatric surgeryMuscle samples before and at 1 year after bariatric surgerySubcutaneous fat samples before and at 3 month and 1 year after bariatric surgeryVisceral fat samples in the great omentum before bariatric surgeryIntestinal samples during gastric by-pass surgeryBlood samples baseline and at at 1, 3 months, 1, 2, 5 years after surgeryEvénements de santé/morbiditéEvénements de santé/mortalitéHealth event/morbidityHealth event/mortalitybefore and after bariatric surgerymonitoring promoteurOuiYesau moins 1 anProspective assessment of clinical and biological features before and after bariatric surgeryLiver samples before and at 1 and 5 years after bariatric surgeryMuscle samples before and at 1 year after bariatric surgerySubcutaneous fat samples before and at 3 month and 1 year after bariatric surgeryVisceral fat samples in the great omentum before bariatric surgeryIntestinal samples during gastric by-pass surgeryBlood samples baseline and at at 1, 3 months, 1, 2, 5 years after surgeryOuiYeshttp://tinyurl.com/Hal-ABOSListe des publications dans HALhttp://tinyurl.com/Pubmed-ABOSListe des publications dans Pubmedhttp://tinyurl.com/Hal-ABOSListe des publications dans HALhttp://tinyurl.com/Pubmed-ABOSListe des publications dans PubmedContacter le responsable scientifiqueContact the investigatorAccès restreint sur projet spécifiqueAccess on specific project onlyAccès restreint sur projet spécifiqueAccess on specific project only