ITMO public health
Last update : 08/17/2016 | Version : 1 | ID : 6927
| General | |
| Identification | |
| Detailed name | Case-Control Study on Patients with Lung Cancer: Specific Genetic Alterations Detectable in the Respiratory Epithelium |
| Sign or acronym | EUELC: European Early Lung Cancer |
| CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation | CNIL |
| General Aspects | |
| Medical area |
Cancer research Pneumology |
| Pathology (details) | Lung cancer |
| Health determinants |
Addictions Genetic Lifestyle and behavior |
| Keywords | genetic changes, exposure, asbestos, smoking, risk factors |
| Scientific investigator(s) (Contact) | |
| Name of the director | Brambilla |
| Surname | Christian |
| Address | Rond point de la Chantourne Site Santé Grenoble 38706 LA TRONCHE |
| Phone | +33 (0)4 76 54 94 09 |
| Christian.Brambilla@ujf-grenoble.fr | |
| Unit | INSERM U823 |
| Organization | Albert Bonniot Research Centre |
| Collaborations | |
| Funding | |
| Funding status |
Public |
| Details | European Union (QLG1-CT-2002-01735) |
| Governance of the database | |
| Sponsor(s) or organisation(s) responsible | Albert Bonniot Research Centre |
| Organisation status |
Public |
| Additional contact | |
| Main features | |
| Type of database | |
| Type of database |
Study databases |
| Study databases (details) |
Case control study |
| Database recruitment is carried out by an intermediary |
A selection of health institutions and services |
| Database recruitment is carried out as part of an interventional study |
No |
| Additional information regarding sample selection. |
Cases selected are patients with non-small cell lung cancer from hospitals participating in the study.
Controls with different pathologies are selected from the same hospital. |
| Database objective | |
| Main objective | To determine if specific genetic alterations occurring in lung cancer are detectable in the respiratory epithelium. |
| Inclusion criteria |
– male or female
– adult |
| Population type | |
| Age |
Adulthood (45 to 64 years) Elderly (65 to 79 years) |
| Population covered |
General population |
| Gender |
Male Woman |
| Geography area |
International |
| Detail of the geography area | 8 European countries: France; Germany; Republic of Ireland; Italy, Netherlands; Poland; Spain and the United Kingdom |
| Data collection | |
| Dates | |
| Date of first collection (YYYY or MM/YYYY) | 2002 |
| Size of the database | |
| Size of the database (number of individuals) |
[1000-10 000[ individuals |
| Details of the number of individuals | 2,476 – 922 cases – 1524 controls |
| Data | |
| Database activity |
Data collection completed |
| Type of data collected |
Declarative data Biological data |
| Declarative data (detail) |
Face to face interview |
| Details of collected declarative data | 45-minute in-person interview with a research interviewer. A standardised lifestyle questionnaire was used to collect information on socioeconomic and demographic characteristics, medical history, family history of cancer, history of tobacco consumption and possible exposure to asbestos. |
| Biological data (detail) | Blood sample – bronchial washing or sputum – tissue samples |
| Presence of a biobank |
Yes |
| Contents of biobank |
Whole blood Fluids (saliva, urine, amniotic fluid, …) Tissues DNA DNAc/RNAm |
| Details of biobank content | Bronchial sputum |
| Health parameters studied |
Health event/morbidity Health event/mortality |
| Procedures | |
| Participant monitoring |
Yes |
| Details on monitoring of participants | Follow-up every 6 months for 36 months. Individuals shall complete a questionnaire on tobacco consumption at each follow-up visit and new biological samples will be collected. |
| Links to administrative sources |
No |
| Promotion and access | |
| Promotion | |
| Link to the document | http://erj.ersjournals.com/content/34/6/1477.long |
| Access | |
| Terms of data access (charter for data provision, format of data, availability delay) | Contact the scientist in charge. |
| Access to aggregated data |
Access on specific project only |
| Access to individual data |
Access on specific project only |
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