ITMO public health
Last update : 08/17/2016 | Version : 1 | ID : 6782
| General | |
| Identification | |
| Detailed name | Case-Control Study of Patients from Neurological Centres: Genetic Profile on Brain Infarction |
| Sign or acronym | GENIC |
| CNIL registration number, number and date of CPP agreement, AFSSAPS (French Health Products Safety Agency) authorisation | CNIL |
| General Aspects | |
| Medical area |
Cardiology Neurology |
| Pathology (details) | Brain infarction |
| Health determinants |
Genetic Medicine Social and psychosocial factors |
| Keywords | nitrogen dioxide, thrombomodulin, genetics |
| Scientific investigator(s) (Contact) | |
| Name of the director | Amarenco |
| Surname | Pierre |
| Address | 46 rue Henri Huchard 75877 Paris |
| pierre.amarenco@bch.aphp.fr | |
| Unit | Inserm698 |
| Organization | Paris Public Hospitals |
| Collaborations | |
| Funding | |
| Funding status |
Mixed |
| Details | CNP Health Foundation — French National Health Insurance Fund for Employees — National Institute of Health and Medical Research —Ministry of Health (Clinical Research Hospital Programme) — Sanofi-Winthrop Laboratories |
| Governance of the database | |
| Sponsor(s) or organisation(s) responsible | Paris Public Hospitals |
| Organisation status |
Public |
| Additional contact | |
| Main features | |
| Type of database | |
| Type of database |
Study databases |
| Study databases (details) |
Case control study |
| Database recruitment is carried out by an intermediary |
A selection of health institutions and services |
| Database recruitment is carried out as part of an interventional study |
No |
| Additional information regarding sample selection. | Subjects recruited within 12 neurological centres participating in the study with symptoms of stroke, not including cerebral haemorrhage. Controls are recruited in the same centres for reasons other than neurological illness. |
| Database objective | |
| Main objective | To describe the association between the endothelial nitric oxide synthase gene and brain infarction. |
| Inclusion criteria |
– Men and women
– Between 18 and 85 years old |
| Population type | |
| Age |
Adulthood (19 to 24 years) Adulthood (25 to 44 years) Adulthood (45 to 64 years) Elderly (65 to 79 years) Great age (80 years and more) |
| Population covered |
General population |
| Gender |
Male Woman |
| Geography area |
National |
| Detail of the geography area | France (12 neurology centres) |
| Data collection | |
| Dates | |
| Date of first collection (YYYY or MM/YYYY) | 2000 |
| Size of the database | |
| Size of the database (number of individuals) |
[500-1000[ individuals |
| Details of the number of individuals | 933 – 470 cases – 463 controls |
| Data | |
| Database activity |
Data collection completed |
| Type of data collected |
Declarative data Paraclinical data Biological data |
| Declarative data (detail) |
Paper self-questionnaire |
| Details of collected declarative data | Demographic information |
| Paraclinical data (detail) | Electrocardiogram; echocardiography; radiography; magnetic resonance cerebral angiography |
| Biological data (detail) | Blood sample |
| Presence of a biobank |
Yes |
| Contents of biobank |
DNA |
| Health parameters studied |
Health event/morbidity |
| Procedures | |
| Participant monitoring |
No |
| Links to administrative sources |
No |
| Promotion and access | |
| Promotion | |
| Link to the document | http://stroke.ahajournals.org/content/31/7/1634.long#fn-1 |
| Link to the document | http://circ.ahajournals.org/content/102/3/313.long |
| Access | |
| Terms of data access (charter for data provision, format of data, availability delay) | Contact the scientist in charge. |
| Access to aggregated data |
Access on specific project only |
| Access to individual data |
Access on specific project only |
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